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020			_a9789813293588
024	7		_a10.1007/978-981-32-9358-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
041	0		_aeng
050		4	_aQP551 _b2019 EB
245	0	0	_aTau Biology _cedited by Akihiko Takashima, Benjamin Wolozin, Luc Buee
250			_aFirst edition 2019
264		1	_aSingapore _bSpringer International Publishing _c2019
300			_a1 recurso en línea (XI, 416 páginas) _b83 ilustraciones, 75 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1184
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_a1) Structure and role of Tau molecule -- (1) Tau structure in solution: FRET study -- (2) Tau structure in solution: NMR study -- (3) Structure of NFT: Biochemical approach -- (4) Structure of NFT: CryoEM approach -- (5) MAPT tau gene and FTDP-17 mutation -- (6) Tau phosphorylation -- (7) Tau acetylation -- (8) Tau truncation -- (9) Tau interacted proteins: interactome -- (10) Tau clearance mechanism -- 2) Tau localization and function -- (11) Localization of Tau -- (12) Axonal transport -- (13) Synaptic localization of tau -- (14) Role of tau in synapse -- (15) Tau in nucleus and nucleic acids -- (16) Tau and the translational stress response -- 3) Tauopathies; pathology, drivers, and marker -- (17) Tau pathology with aging -- (18) Clinical symptom and pathology of FTD including FTDP-17 -- (19) Chronic Traumatic Encephalopathy -- (20) Myotonic dystrophies -- (21) Tau PET -- (22) Tau PET/connectome/fMRI -- (23) Stress -- (24) Diabetes -- (25) Relationship between ApoE and tau -- (26) Relationship between Ab and tau -- 4) Tau aggregation, and therapy -- (27) Tau Oligomer -- (28) Tau droplet formation -- (29) Stress granule -- (30) Tau secretion -- (31) Tau seeding -- (32) Prion-like Tau propagation -- (33) Experimental models for tauopathies -- (34) Dementia therapy targeting tau -- (35) Tau aggregation inhibitor.
520	3		_aThis book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.
988			_aSpringer_BiomedLife_31032020
650		7	_2embne _aProteínas _9139861
650		7	_2embne _9144620 _aAlzheimer, Enfermedad de _xTratamiento
650		7	_2embne _aNervios periféricos _9670165
700	1		_aTakashima, Akihiko. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aWolozin, Benjamin. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBuee, Luc. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service)
776	0	8	_iPrinted edition: _z9789813293571
776	0	8	_iPrinted edition: _z9789813293595
776	0	8	_iPrinted edition: _z9789813293601
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://dx.doi.org/10.1007/978-981-32-9358-8
942			_2lcc _cLE _n0
998			_b04/2020 _dz _eb _zSI