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020			_a9789811529023
024	7		_a10.1007/978-981-15-2902-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
041	0		_aeng
050		4	_aRD86.K4 _b2020 EB
245	0	0	_aKetamine : _bFrom Abused Drug to Rapid-Acting Antidepressant _cedited by Kenji Hashimoto, Soichiro Ide, Kazutaka Ikeda.
250			_aFirst edition 2020
264		1	_aSingapore _bSpringer International Publishing _c2020
300			_a1 recurso en línea (V, 189 páginas) _b27 ilustraciones, 13 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_a1.Determination of ketamine in the river of China -- 2.Ketamine abuse in Taiwan -- 3.Ketamine problem in Hong Kong -- 4. Hair analysis of ketamine -- 5. Brain imaging of ketamine abusers -- 6.Management of complications of ketamine abuse -- 7.Action site of ketamine in the NMDA receptor channel -- 8.Synaptic modulation in the effect of ketamine -- 9.Rodents whole-brain imaging in the effects of ketamine -- 10. Behavioral pharmacology of ketamine: An overview of preclinical studies -- 11.Antidepressant potential of ketamine enantiomers -- 12.Effects of ketamine on pain-related depression -- 13.Role of gut microbiota in the antidepressant actions of ketamine and its enantiomers -- 14. The role of NMDA receptor GluN2D subunit in the effects of ketamine and enantiomers -- 15.Roles of the lateral habenula in the actions of ketamine -- 16.Comparison of antidepressant action of ketamine and group II mGlu receptor antagonists -- 17.Antidepressant effects of ketamine in Taiwanese patients with treatment-resistant depression.
520	3		_aThis book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants. .
988			_aSpringer_BiomedLife_31032020
650		7	_2embne _9673135 _aKetamina
650		7	_2embne _9138500 _aAnestésicos
700	1		_aHashimoto, Kenji. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aIde, Soichiro. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aIkeda, Kazutaka. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service)
776	0	8	_iPrinted edition: _z9789811529016
776	0	8	_iPrinted edition: _z9789811529030
776	0	8	_iPrinted edition: _z9789811529047
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://dx.doi.org/10.1007/978-981-15-2902-3
942			_2lcc _cLE _n0
998			_b04/2020 _dz _eb _zSI