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020 _a9789813297555
024 7 _a10.1007/978-981-32-9755-5
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aQP551
_b2019 EB
245 0 0 _aReverse Phase Protein Arrays :
_bFrom Technical and Analytical Fundamentals to Applications
_cedited by Tesshi Yamada, Satoshi S. Nishizuka, Gordon B. Mills, Lance A. Liotta
250 _aFirst edition
264 1 _aSingapore
_bSpringer International Publishing
_c2019
300 _a1 recurso en línea (VIII, 266 páginas)
_b64 ilustraciones, 60 ilustraciones a color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aAdvances in Experimental Medicine and Biology
_x0065-2598
_v1188
490 0 _aBiomedical and Life Sciences (Springer-11642)
505 0 _aChapter 1: Origin and future of RPPA technology -- Chapter 2: Lysate preparation -- Chapter 3: Printing platforms 1 -- Chapter 4: Printing platforms 2 -- Chapter 5: Analytical platforms 1 -- Chapter 6: Analytical platforms 2 -- Chapter 7: Analytical platforms 3 -- Chapter 8. Antibody screening 1 -- Chapter 9. Antibody screening 2 -- Chapter 10. Antibody screening 3 -- Chapter 11. Integrative analysis for genomics and RPPA -- Chapter 12. Integrative analysis of multiple platforms of RPPA -- Chapter 13. Drug screening platforms and RPPA -- Chapter 14. RPPA in small population analysis -- Chapter 15: Molecular target identification using RPPA -- Chapter 16: RPPA in clinical trials -- Chapter 17: RPPA and future medicine.
520 3 _aThis book provides practical guidance on all aspects of reverse phase protein array (RPPA) technology, which permits the quantification of protein levels in cell or tissue lysates. In addition, the latest results are presented from laboratories across the world where experts are successfully running the challenging RPPA data platform. After an introductory chapter by the inventor of the RPPA technique, the demanding task of lysate preparation is explained. Subsequent chapters review printing platforms and analytical platforms and discuss antibody screening in detail. The role of RPPA data in integrative analyses is thoroughly examined, and the various applications of RPPA, for example to identify molecular targeting drugs or evaluate cancer drug efficacy, are discussed with reference to the latest knowledge. It is hoped that the book will foster the implementation of RPPA by documenting the practical details of the technology and by revealing its great potential. It will be of high value for researchers who plan to build an RPPA platform in their institute and for researchers, clinicians, and companies who use RPPA through collaboration with an existing RPPA facility.
988 _aPrimersemestre_2020_BiomedLife
650 7 _2embne
_aProteínas
_9139861
700 1 _aYamada, Tesshi
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aNishizuka, Satoshi S
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aMills, Gordon B
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aLiotta, Lance A
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789813297548
776 0 8 _iPrinted edition:
_z9789813297562
776 0 8 _iPrinted edition:
_z9789813297579
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-32-9755-5
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
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