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020			_a9789811322181
024	7		_a10.1007/978-981-13-2218-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC394.D35 _b2019 EB
245	0	0	_aInsights into Human Neurodegeneration: Lessons Learnt from Drosophila _cedited by Mousumi Mutsuddi, Ashim Mukherjee.
250			_aFirst edition
264		1	_aSingapore _bSpringer International Publishing _c2019
300			_a1 recurso en línea (X, 467 páginas) _b48 ilustraciones, 43 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aChapter 1. Introduction to Drosophila as a model organism -- Chapter 2. Methods for creating fly models in order to understand molecular mechanism of neurological diseases -- Chapter 3. Neurodegeneration: Lessons learnt from forward genetic screens in Drosophila -- Chapter 4. Drosophila neural stem cells, a primer for understanding mammalian neurobiology -- Chapter 5. Understanding motor disorders using flies -- Chapter 6. Metabolic alterations amalgamated with neurodegenerative diseases -- Chapter 7. Notch signalling in neurodegenerative disease -- Chapter 8. Drosophila model of neurofibrillar tangles -- Chapter 9. Unraveling Alzheimer's disease using Drosophila -- Chapter 10. Modelling Human Parkinson's disease in fly -- Chapter 11. Post-translational modifications: A mystery to unravel Huntington's disease -- Chapter 12. Understanding the pathogenicity of non-coding RNA expansion associated neurodegenerative disorders -- Chapter 13. Expanding roles of RNA binding proteins in neurodegeneration -- Chapter 14. Hereditary Spastic Paraplegia Disease in Drosophila -- Chapter 15. Drosophila as a model system for the identification of pharmacological therapies in neurodegenerative diseases.
520	3		_aThis book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson's, Spinomuscular Atrophy, Huntington's diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.
988			_aPrimersemestre_2020_BiomedLife
650		7	_2embne _9313064 _aSistema nervioso _xDegeneración
700	1		_aMutsuddi, Mousumi _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aMukherjee, Ashim _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789811322174
776	0	8	_iPrinted edition: _z9789811322198
776	0	8	_iPrinted edition: _z9789813299139
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-2218-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE _n0
998			_b02/2020 _dz _ek _zSI