000			04163nam a2200433 c 4500
999			_c117984 _d117984
001			117984
003			ES-MaUEC
005			20230102113837.0
006			a||||fo|||| 00| 0
007			cr nn nnnaamaa
008			191219s2019 gw a o |||| 0|eng d
020			_a9783030287030
024	7		_a10.1007/978-3-030-28703-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC862.I53 _bM654 2019
245	0	0	_aMolecular Genetics of Inflammatory Bowel Disease _cedited by Charlotte Hedin, John D. Rioux, Mauro D'Amato.
250			_aSecond edition
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (X, 402 páginas) _b37 ilustraciones, 35 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPart 1: The Foundation of IBD Genetics, Human and Animal Studies -- A Primer on IBD: Phenotypes, Diagnosis, Treatment and Clinical Challenges -- Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies -- Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease -- Part 2: The Genetic and Molecular Makeup of Inflammatory Bowel Disease -- Complex Disease Genes and their Discovery -- The Genetics of Crohn's Disease -- Genetics of Ulcerative Colitis -- Genetic Overlap between Inflammatory Bowel Disease and Other Diseases -- Molecular Profiling of IBD Subtypes/Response to Therapy -- Epigenetics of Inflammatory Bowel Disease -- Part 3: Pathogenetic Pathways in Inflammatory Bowel Disease -- Nod1 and Nod2 and the Immune Response to Bacteria -- The IL-23-Th17 Axis in Intestinal Inflammation -- Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics -- The Epithelial Barrier -- Host Interactions with Bacteria: From "Entente Cordiale" to "Casus Belli" -- Cytokines in Inflammatory Bowel Disease -- Part 4: Concluding Remarks and Future Perspectives -- Towards Personalized Therapy in Inflammatory Bowel Disease -- Index.
520	3		_aInflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn's disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.
988			_aPrimersemestre_2020_BiomedLife
650		7	_2embne _9185357 _aIntestinos _xEnfermedades
700	1		_aHedin, Charlotte _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aRioux, John D _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _984853
700	1		_aD'Amato, Mauro _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _984852
710	2		_aSpringerLink (Online service) _9106996
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783030287023
776	0	8	_iPrinted edition: _z9783030287047
776	0	8	_iPrinted edition: _z9783030287054
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-28703-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE _n0