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020			_a9789813293939
024	7		_a10.1007/978-981-32-9393-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC280 .P25 _b2019 EB
245	0	0	_aExploring Pancreatic Metabolism and Malignancy _cedited by Ganji Purnachandra Nagaraju, Aramati BM Reddy.
250			_aFirst edition
264		1	_aSingapore _bSpringer International Publishing _c2019
300			_a1 recurso en línea (XII, 268 páginas) _b35 ilustraciones, 29 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aChapter 1. Biology of pancreas and possible diseases -- Chapter 2. Pancreatitis: Clinical aspects of inflammatory phenotypes -- Chapter 3. Diabetes and Pancreatic Cancer - A Bidirectional Relationship Perspective -- Chapter 4. Metabolic Adaptations in Diabetes Mellitus and Cancer -- Chapter 5. Role of Mitochondria in pancreatic metabolism, diabetes and cancer -- Chapter 6. Targeting Mitochondrial Enzymes in Pancreatic Cancer -- Chapter 7. Diabetes with Pancreatic ductal adenocarcinoma -- Chapter 8. Role of Inflammatory Cytokines in the initiation and progression of Pancreatic Cancer -- Chapter 9. Perspectives and molecular understanding of pancreatic cancer stem cells -- Chapter 10. The Role of Hypoxia Inducible Factor-1α in Pancreatic Cancer and Diabetes Mellitus -- Chapter 11. Role of Heat shock protein 90 in Diabetes and Pancreatic Cancer Management -- Chapter 12. Insulin resistance is a common core tethered to diabetes and pancreatic cancer risk -- Chapter 13. Immunotherapy for Diabetogenic Pancreatitis and Pancreatic Cancer: An Update -- Chapter 14. Exosomes: Mediators and Therapeutic Targets of Diabetes and Pancreatic Cancer -- Chapter 15. Methods and models in exploring pancreatic functions.
520	3		_aThis book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery. Metabolic syndrome, which includes adnominal obesity, hypertension, dyslipidemia, and hyperglycemia, has recently been shown to play an important role in the etiology and progression of various cancers. Further, obesity and diabetes have been associated with an increased incidence of gastric cancers. The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy. Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy.
988			_aPrimersemestre_2020_BiomedLife
650		7	_2embne _9194247 _aPáncreas _xCáncer
700	1		_aNagaraju, Ganji Purnachandra _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBM Reddy, Aramati _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789813293922
776	0	8	_iPrinted edition: _z9789813293946
776	0	8	_iPrinted edition: _z9789813293953
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-32-9393-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE _n0
998			_b04/2020 _dz _eh _zSI