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020 _a9789811387197
024 7 _a10.1007/978-981-13-8719-7
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aQP552.A436
_b2019 EB
245 0 0 _aProtein Allostery in Drug Discovery
_cedited by Jian Zhang, Ruth Nussinov.
250 _aFirst edition
264 1 _aSingapore
_bSpringer International Publishing
_c2019
300 _a1 recurso en línea (XII, 384 páginas)
_b103 ilustraciones, 82 ilustraciones a color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aAdvances in Experimental Medicine and Biology
_x0065-2598
_v1163
490 0 _aBiomedical and Life Sciences (Springer-11642)
505 0 _aChapter 1. Allostery in Drug Development -- Chapter 2. Dynamic Protein Allosteric Regulation and Disease -- Chapter 3. Protein Allostery in Rational Drug Design -- Chapter 4. Progress in Allosteric Database -- Chapter 5. Correlation between Allosteric and Orthosteric Sites -- Chapter 6. Characteristics of Allosteric Proteins, Sites and Modulators -- Chapter 7. Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins -- Chapter 8. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands -- Chapter 9. Interrogating Regulatory Mechanisms in Signal-ling Proteins by Allosteric Inhibitors and Activators: A Dynamic View through the Lens of Residue Interaction Network -- Chapter 10. GPCR Allosteric Modulator Discovery -- Chapter 11. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors -- Chapter 12. Allosteric regulation of protein kinases downstream of PI3-kinase signaling. Chapter 13. Allosteric Modulators of Protein-Protein Interactions (PPIs) -- Chapter 14. Allosteric Modulation of Intrinsically Disordered Proteins -- Chapter 15. Engineering Allostery into Proteins.
520 3 _aThe book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery-as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc. .
988 _aPrimersemestre_2020_BiomedLife
650 7 _2embne
_aProteínas
_9139861
700 1 _aZhang, Jian
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_932630
700 1 _aNussinov, Ruth
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789811387180
776 0 8 _iPrinted edition:
_z9789811387203
776 0 8 _iPrinted edition:
_z9789811387210
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-8719-7
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
_n0
998 _b03/2020
_dz
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