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020			_a9783030258900
024	7		_a10.1007/978-3-030-25890-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC931.O73 _b2019 EB
245	0	0	_aOsteosarcopenia. _bBone, Muscle and Fat Interactions _cedited by Gustavo Duque.
250			_aFirst edition
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (XVI, 383 páginas) _b42 ilustraciones, 28 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aDedication -- Foreword -- Preface -- Acknowledgements -- PART I Biology of Muscle and Bone -- Muscle and Bone Biology -- Mesenchymal stem cells as regulators of bone, muscle, and fat formation -- Age-related changes in muscle and bone -- Cross-talk between muscle and bone -- Role of connexins and pannexins in bone and muscle mass and function -- Osteosarcopenia as a Lipotoxic Disease -- The endocrine actions of undercarboxylated osteocalcin in skeletal muscle: effects and mechanisms -- Sex steroid hormones and osteosarcopenia -- Calciotropic hormones and osteosarcopenia -- Genetics of Osteosarcopenia -- PART II Clinical Characteristics -- Diagnosis of Osteosarcopenia - clinical -- Diagnosis of Osteosarcopenia - Imaging -- Diagnosis of osteosarcopenia - Biochemistry and pathology -- Osteosarcopenic obesity -- Non-pharmacological interventions for osteosarcopenia -- The Falls and Fractures Clinic - An integrated model of care for osteosarcopenic patients -- Index.
520	3		_aThis edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions - including the role of local bone and muscle fat - followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.
988			_aPrimersemestre_2020_BiomedLife
650		7	_2embne _9141478 _aOsteoporosis
700	1		_aAristizábal Duque, Gustavo _eeditor literario _0(orcid)0000-0001-8126-0637 _1https://orcid.org/0000-0001-8126-0637 _4edt _4http://id.loc.gov/vocabulary/relators/edt _926678
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783030258894
776	0	8	_iPrinted edition: _z9783030258917
776	0	8	_iPrinted edition: _z9783030258924
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-25890-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE _n0
998			_b05/2020 _dz _ea _zSI