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020			_a9783030332495
024	7		_a10.1007/978-3-030-33249-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC204 _b2019 EB
245	0	0	_aPertussis Infection and Vaccines _bAdvances in Microbiology, Infectious Diseases and Public Health Volume 12 _cedited by Giorgio Fedele, Clara Maria Ausiello.
250			_aFirst edition
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (VIII, 170 páginas) _b10 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aAdvances in Microbiology Infectious Diseases and Public Health _x2365-2675 _v1183
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aHow Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis -- Molecular epidemiology of Bordetella pertussis -- Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis -- Functional Programming of Innate Immune Cells in Response to Bordetella pertussis Infection and Vaccination -- Superior B. pertussis Specific CD4+ T-Cell Immunity Imprinted by Natural Infection -- Human Immune Responses to Pertussis Vaccines -- New Pertussis Vaccines: A Need and a Challenge -- Pertussis: Identification, Prevention and Control -- Pertussis in Low and Medium Income Countries: A Pragmatic Approach -- Clinical Findings and Management of Pertussis -- Pertussis Vaccines and Vaccination Strategies. An Ever-Challenging Health Problem.
520	3		_aThis book provides a comprehensive overview of pertussis - also known as whooping cough. The first part discusses the evolution the genus Bordetellae and the molecular epidemiology of B. pertussis, while the following chapters focus on the role of B. pertussis virulence factors in infection and disease and on the mechanisms of the immune response to infection and vaccination. The book also explores the prevention and control of the disease as well as its clinical management, with the finally section addressing vaccination, from improved immunization strategies to novel vaccines. Pertussis remains one of the most poorly controlled vaccine-preventable diseases around the globe. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In recent decades, changes in pertussis epidemiology have been noted, likely related to the use of acellular pertussis vaccines, which in many countries have replaced older-generation, whole-cell pertussis vaccines. Several years after their introduction, it is becoming apparent that immunity conferred by acellular vaccines wanes more rapidly than expected. Unlike whole-cell vaccines, acellular vaccines, while protecting against the disease, do not seem to prevent colonization and transmission. Increasing incidence among adolescents and adults makes them a reservoir for transmission to unimmunized infants, who in turn are at risk of severe disease and death. This book is a valuable resource for researchers and clinicians in the field of medical microbiology, vaccine research and infectious diseases.
988			_aPrimersemestre_2020_BiomedLife
650		7	_2embne _9672516 _aTosferina
700	1		_aFedele, Giorgio _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aAusiello, Clara Maria _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783030332488
776	0	8	_iPrinted edition: _z9783030332501
776	0	8	_iPrinted edition: _z9783030332518
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-33249-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE _n0
998			_b03/2020 _dz _ek _zSI