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020 _a9783030326562
024 7 _a10.1007/978-3-030-32656-2
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRC280.P7
_b2019 EB
245 0 0 _aProstate Cancer
_bCellular and Genetic Mechanisms of Disease Development and Progression
_cedited by Scott M. Dehm, Donald J. Tindall.
250 _aSecond edition
264 1 _aCham, Switzerland
_bSpringer International Publishing
_c2019
300 _a1 recurso en línea (XIII, 476 páginas)
_b48 ilustraciones, 44 ilustraciones a color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aAdvances in Experimental Medicine and Biology
_x0065-2598
_v1210
490 0 _aBiomedical and Life Sciences (Springer-11642)
505 0 _aDiet and Lifestyle in Prostate Cancer -- Dietary Carcinogens and DNA Adducts in Prostate Cancer.-Genetic, Environmental, and Nuclear Factors Governing Genomic -- Cells of Origin for Prostate Cancer -- Prostate Cancer Genomic Subtypes -- Prostate Cancer Transcriptomic Subtypes -- Immunological complexity of the prostate cancer microenvironment influences the response to immunotherapy -- The Tumor Microenvironments of Lethal Prostate Cancer -- The Bone Microenvironment in Prostate Cancer Metastasis -- Prostate Cancer Energetics and Biosynthesis -- Canonical and Noncanonical Androgen Metabolism and Activity -- Germline and Somatic Defects in DNA Repair Pathways in Prostate Cancer -- The Role of RB in Prostate Cancer Progression -- Interplay among PI3K/AKT, PTEN/FOXO and AR signaling in prostate cancer -- Androgen Receptor Dependence -- WNT/BETA-CATENIN SIGNALING AND PROSTATE CANCER THERAPY RESISTANCE -- Epigenetic Regulation of Chromatin in Prostate Cancer -- Oncogenic ETS factors in prostate cancer -- Neural Transcription Factors in Disease Progression -- Index.
520 3 _aThe purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.
988 _aPrimersemestre_2020_BiomedLife
650 7 _2embne
_aPróstata
_xCáncer
_9182337
700 1 _aDehm, Scott M
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aTindall, Donald J
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_984722
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783030326555
776 0 8 _iPrinted edition:
_z9783030326579
776 0 8 _iPrinted edition:
_z9783030326586
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-32656-2
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
_n0
998 _b03/2020
_dz
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