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020			_a9783030294038
024	7		_a10.1007/978-3-030-29403-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC756 _b2019 EB
245	0	0	_aStem Cell-Based Therapy for Lung Disease _cedited by Janette K. Burgess, Irene H. Heijink.
250			_aFirst edition
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (VIII, 259 páginas) _b28 ilustraciones, 26 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_a1 Chronic lung pathologies that require repair and regeneration -- I Stem/stromal cells populations in the lung -- 2 Characterization of stromal/stem cells in the lung and translation of knowledge of stem/stromal cell population to human lung -- 3 Comparison of the regenerative potential for lung tissue of mesenchymal stromal cells from different sources/locations within the body -- 4 The potential of factors released from mesenchymal stromal cells as therapeutic agents in the lung -- II Preclinical evidence and clinical applications in Chronic Lung Diseases -- 5 Preclinical evidence for the role of stem/stromal cells in COPD -- 6 Clinical application of stem/stromal cells in COPD -- 7 Evidence for the role of stem/stromal cells in lung fibrosis -- 8 Preclinical evidence for the role of stem/stromal cells and their therapeutic potential in treating BPD and PAH -- 9 Crispr-Cas9 editing in induced pluripotent stem cells: a way forward for treating Cystic Fibrosis? -- 10 Clinical application of stem/stromal cells in cystic fibrosis -- 11 Preclinical evidence for the role of stem/stromal cells in targeting ARDS -- 12 The safety and efficiency of addressing ARDS using stem cell therapies in clinical trials -- III Stem cell delivery systems and devices -- 13 Spraying as route of delivery for stem cells to the lungs -- IV Conclusion -- 14 Conclusion.
520	3		_aThis book presents state-of-the-art pre-clinical models and clinical applications of stem-cell-based therapies applied to different lung diseases, with a special focus on the translation of bench data into clinical studies. Starting with the assumption that abnormal lung tissue repair and regeneration has emerged as the driving force underlying pathogenesis and progression in many lung diseases, it sheds new light on the potential of stem/stromal cells as drivers of repair and sources of reparative factors in the lung. The first part of the book offers an overview of stem cell types and mechanisms involved in lung development, homeostasis, repair and regeneration, and reveals the crucial role of the extracellular matrix within the lung microenvironment. In the second part, leading experts present the latest pre-clinical evidence and clinical applications of stem-cell-based therapies in a wide variety of lung diseases, ranging from COPD and lung fibrosis to other rare lung diseases. The last section discusses stem cell delivery systems and devices, such as aerosolised spray application. This book appeals to pneumologists, stem cell and matrix biologists, as well as bioengeneers with a special interest in regenerative medicine applied to pulmonary diseases.
988			_aPrimersemestre_2020_BiomedLife
650		7	_aPulmones _xEnfermedades _2embne _9168957
650		7	_aCélulas madre _2embne _9160528
700	1		_aBurgess, Janette K _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aHeijink, Irene H _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783030294021
776	0	8	_iPrinted edition: _z9783030294045
776	0	8	_iPrinted edition: _z9783030294052
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-29403-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE _n0
998			_b05/2020 _dz _ea _zSI