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020			_a9789813297173
024	7		_a10.1007/978-981-32-9717-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQR185.8.T2 _b2019 EB
245	0	0	_aCo-signal Molecules in T Cell Activation _bImmune Regulation in Health and Disease _cedited by Miyuki Azuma, Hideo Yagita.
250			_aFirst edition
264		1	_aSingapore _bSpringer International Publishing _c2019
300			_a1 recurso en línea (VI, 326 páginas) _b22 ilustraciones, 21 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1189
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPart I: Basic Understanding of Co-signal Molecules in T cell activation -- Chapter 1 Co-signal molecules in T cell activation -- Chapter 2 The CD28-B7 family of co-signaling molecules -- Chapter 3 The TNF YNFR family of co-signal molecules -- Chapter 4 Signal transduction via co-stimulatory and co-inhibitory receptors -- Chapter 5 Molecular dynamics of co-signal molecules in t cell activation -- Chapter 6 Role of co-stimulatory molecules in T helper cell differentiation -- Chapter 7 Control of regulatory T cells by co-signal molecules -- Part II: Co-signal Molecules in Health and Disease -- Chapter 8 Stimulatory and inhibitory co-signals in autoimmunity -- Chapter 9 Co-signaling molecules in neurological diseases -- Chapter 10 Costimulation blockade in transplantation -- Chapter 11 Immunotherapy targeting co-signal molecules. .
520	3		_aThis book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science. .
988			_aPrimersemestre_2020_BiomedLife
650		7	_2embne _aLinfocitos T _9144344
700	1		_aAzuma, Miyuki _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aYagita, Hideo _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789813297166
776	0	8	_iPrinted edition: _z9789813297180
776	0	8	_iPrinted edition: _z9789813297197
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-32-9717-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE _n0
998			_b02/2020 _dz _ek _zSI