000			03963nam a22004095i 4500
988			_aSpringer_Medicine_2019
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005			20230110040254.0
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008			190617s2019 gw | s |||| 0|eng d
020			_a9783319730820
024	7		_a10.1007/978-3-319-73082-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC649 _b2019 EB
245	0	0	_aPolyendocrine Disorders and Endocrine Neoplastic Syndromes _cedited by Annamaria Colao, Marie-Lise Jaffrain-Rea, Albert Beckers.
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2019.
300			_a1 recurso en línea (X, 390 páginas)
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aEndocrinology _x2510-1927
490	0		_aMedicine (Springer-11650)
505	0		_aIntroduction.-Auto-immune polyglandular syndromes (APS): an overview -- The natural history of APS1: pathogenesis and long term follow-up -- The genetics of AIRE: an update -- Auto-antibodies in polyendocrine auto-immune disorders: an update -- Rare forms of endocrine and systemic auto-immune disorders: IPEX and "other POEMS" -- Auto-immune endocrine diseases and cancer immunotherapy -- Part 2: MEN1: an update on molecular diagnosis and clinical implications -- MEN2: an update on molecular diagnosis and clinical implications -- MEN4 and other MEN1-like syndrome -- Genetic alterations in the cAMP pathway: MAS, Carney complex (and AIP?) -- Endocrine tumours associated with SDHx mutations: pheochromocytomas, paragangliomas and pituitary adenomas. -- Endocrine tumours in complex genetic disorders: lessons from pheochromocytomas and hyperparathyroidism.
520			_aThis comprehensive reference book is meant to support clinicians in the diagnosis and treatment of polyendocrine diseases and endocrine neoplastic syndromes. Although a large majority of endocrine diseases present as sporadic cases, an increasing proportion can be identified as part of a polyendocrine or systemic syndrome. These include autoimmune endocrine diseases, which may be part of autoimmune polyendocrine disorders (APS) or rare complex disorders such as POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) or IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndromes. On the other hand, endocrine tumors may develop in a variety of clinical conditions, including multiple endocrine neoplasia (MEN) syndromes, syndromic diseases such as McCune Albright or Carney's complex, or peculiar familial associations such as pheochromocytoma/paraganglioma syndromes. The book discusses the significant advances that have been made in the clinical and genetic characterization of such entities, with major implications in terms of diagnosis and clinical management, including familial screening, as well as in terms of multidisciplinarity. This volume is intended for clinicians, residents, specialists and physicians involved in the diagnosis and treatment of affected patients, including specialists in endocrinology, internal medicine, oncology and genetics. .
650		7	_2embne _aEndocrinología _9139372
650		7	_2embne _9138582 _aDiabetes
700	1		_aColao, Annamaria _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aJaffrain-Rea, Marie-Lise _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBeckers, Albert _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
773	0		_tSpringer Nature Living Reference
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-73082-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b01/2020 _eIG _zSI