000			05855nam a22004335i 4500
988			_aSpringer_Engineering_2019
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005			20230104140226.0
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008			190617s2019 gw | s |||| 0|eng d
020			_a9783319715308
024	7		_a10.1007/978-3-319-71530-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRD598.55 _b2019 EB
245	0	0	_aTissue-Engineered Vascular Grafts _cedited by Beat Walpoth, Helga Bergmeister, Gary Bowlin, Deling Kong, Joris Rotmans, Peter Zilla.
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2019.
300			_a1 recurso en línea
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aTissue Engineering and Regeneration
490	0		_aEngineering (Springer-11647)
505	0		_a1. Clinical Aspects and Limitations of Vascular Grafts (Peter ZILLA, SA) -- 2. Synthetic Materials for Vascular Scaffolds.- 3. Mechanical Testing of Vascular Grafts (Christian GRASL and Martin STOIBER, Heinz SCHIMA, AU) --  4. In vitro Testing of Engineered Vascular Grafts.- 5. In Vivo Testing and Animal Models for Vascular Grafts (Helga BERGMEISTER, AU, Bruno PODESSER, AU) -- 6. Decellularized Vascular Grafts for VTE (Axel HAVERICH, Sotiris KOROSSIS, Andres HILFIKER, DE) -- 7. Degradable and Non-degradable Vascular Scaffolds (Yadong WANG, William WAGNER, USA) -- 8. In Vivo Vascular Tissue Engineering - Long-term Results (Beat WALPOTH, CH) -- 9. Cell-Assembled Extracellular Matrix for Building Vascular Grafts (Nicolas L'HEUREUX, FR) -- 10. Cell-based/Seeding of Vascular Grafts (David VORP, Justin Sol WEINBAUM, Darren G HASKETT, USA) --  11. Vascular Tissue Engineering: the role of 3-D printing (Ali KHADEMHOSSEINI, Yu Shrike ZHANG, USA) -- 12. Autologous Mandril-based VTE (Joris ROTMANS, NL) -- 13. The Role of Tropoelastin in VTE (Tony WEISS, AUS) -- 14. Vascular Grafts made of Cell Sheets.- 15. Vascular Tissue Engineering: Pathology, Mechanisms, and Translational Implications (Carlijn BOUTEN, NL, Fred SCHOEN, USA).- 16. Models to study cardiovascular calcification relevant to tissue engineering (Elena AIKAWA, USA).-  17. The incorporation and release of bioactive molecules in Vascular Grafts (Deling KONG, CN) -- 18. Functionalization/Coating of Vascular Grafts" including "cell surface interaction" (Olivier FELIX, Gero DECHER, FR, Mitsuru AKASHI, JP) -- 19. Clinical application of VTE for children (Toshi SHINOKA, Christopher BREUER, USA) -- 20. Bioengineered Human Acellular Vessels (Laura NIKLASON, Jeffrey H. LAWSON, USA).
520			_aCardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone.   Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery.   Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE.  All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications.   The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment.   Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.
650		7	_2embne _9669481 _aVálvulas cardíacas _xCirugía
700	1		_aWalpoth, Beat _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBergmeister, Helga _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBowlin, Gary _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aKong, Deling _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aRotmans, Joris _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aZilla, Peter _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
773	0		_tSpringer Nature Living Reference
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-71530-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b01/2020 _eIG _zSI