000			03745nam a22004215i 4500
988			_aSpringer_BiomedLife_2019
999			_c116802 _d116802 _x1
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005			20230110040246.0
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008			190930s2019 si | s |||| 0|eng d
020			_a9789811376474
024	7		_a10.1007/978-981-13-7647-4 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRS201.V43 _b2019 EB
245	0	0	_aDrug Transporters in Drug Disposition, Effects and Toxicity _cedited by Xiaodong Liu, Guoyu Pan.
250			_a1st ed. 2019.
264		1	_aSingapore _bSpringer International Publishing _c2019
300			_a1 recurso en línea (X, 580 páginas) _b38 ilustraciones, 18 ilustraciones
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF _2rda
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1141
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aOverview: role of drug transporters in drug disposition and its clinical significance -- ABC family transporters -- SLC family transporters -- Current research method in transporter study -- Transporter-mediated drug-drug interactions and their significance -- Roles of hepatic drug transporters in drug disposition and liver toxicity -- Roles of renal drug transporter in drug disposition and renal toxicity -- Intestinal transporter associated toxicity and absorption -- Contributions of drug transporters to blood-brain barriers -- Contributions of drug transporters to blood-retinal barrier(BRB) -- Contributions of drug transporters to blood-placental barrier -- ABC transporter-mediated multidrug-resistant cancer.
520	3		_aThis book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
650		7	_2embne _aMedicamentos _xEfectos fisiológicos _9168752
700	1		_aLiu, Xiaodong _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aPan, Guoyu _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9789811376467
776	0	8	_iPrinted edition: _z9789811376481
776	0	8	_iPrinted edition: _z9789811376498
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-7647-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b01/2020 _ek _zSI