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988			_aSpringer_BiomedLife_2019
999			_c116785 _d116785 _x1
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003			ES-MaUEC
005			20230104140159.0
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008			190617s2019 gw | s |||| 0|eng d
020			_a9783319645971
024	7		_a10.1007/978-3-319-64597-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQR182 _b2019 EB
245	0	0	_aHandbook of Immunosenescence : _bBasic Understanding and Clinical Implications _cedited by Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_b1 recurso en línea
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF _2rda
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aMethods and Models for Studying Immunosenescence -- Methods for studying human immunosenescence in tissues other than blood -- Mechanisms - Receptors and Signal Transduction -- Clinical Relevance in Disease States - Infection -- Modulation -- Nutrition.
520	3		_a"Immunosenescence" is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. Indeed, during the almost 10 years that have passed since the first edition of this Handbook, a wealth of additional information has emerged from animal models and also from increasingly available human data. Numerous new aspects of the immune changes with aging have emerged, while others became less prominent. The application of the new multi-"omics" techniques in immunology have revolutionized our molecular understanding of basic immune mechanisms. The extended and revisited concept of Inflamm-aging sheds a new light on the intricate relationships among immunosenescence and inflamm-aging. The new concept of inflamm-aging integrates different emerging experimental data such as those pertaining to the senescence-associated secretory phenotype and responses to damage. "Geroscience" is emphasising the role of immune changes during life in all manner of age-related chronic diseases such as cancer and neurodegenerative disorders. The field is poised to be in a position to translate these accumulated data into the clinical setting via a better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This new edition of the Handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in both basic research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, microbiome, lipids, vaccination and the burning question "can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?".
650		7	_2embne _aInmunología _9138330
700	1		_aFulop, Tamas _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aFranceschi, Claudio _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aHirokawa, Katsuiku _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aPawelec, Graham _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
773	0		_tSpringer Nature Living Reference
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-64597-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b01/2020 _ek _zSI