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988			_aSpringer_BiomedLife_2019
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008			190627s2019 gw | s |||| 0|eng d
020			_a9783030118129
024	7		_a10.1007/978-3-030-11812-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC268.4 _b2019 EB
245	0	0	_aMolecular and Cell Biology of Cancer : _bWhen Cells Break the Rules and Hijack Their Own Planet _cedited by Rita Fior, Rita Zilhão.
250			_a1st ed. 2019.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (IX, 216 páginas) _b71 ilustraciones
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF _2rda
490	0		_aLearning Materials in Biosciences _x2509-6125
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPreface -- Molecular and Cell Biology of Cancer when cells break the rules and hijack their own planet -- Cancer as an Evolutionary Process -- Cell signaling in cancer -- The cell cycle, cytoskeleton and cancer -- Genomic Instability: DNA Repair and Cancer -- Cell metabolism in cancer - an energetic switch -- Cancer immunoediting and hijacking of the immune system -- Angiogenesis - vessels recruitment by tumor cells -- Tumor niche disruption and metastasis: the role of epithelial-mesenchymal transition (EMT) -- Case studies - Molecular Pathology perspective and impact on oncologic patients' management -- Index.
520	3		_aThis textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg "Hallmarks of Cancer" are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book's closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease.
650		7	_2embne _9273952 _aCáncer _xAspectos genéticos
700	1		_aFior, Rita _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aZilhão, Rita _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030118112
776	0	8	_iPrinted edition: _z9783030118136
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-11812-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b01/2020 _ek _zSI