000			04605nam a2200433 i 4500
988			_aSpringer_BiomedLife_2019
999			_c115930 _d115930 _x1
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003			ESmaUEC
005			20230110040243.0
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008			190730s2019 gw | s |||| 0|eng d
020			_a9783030163730
024	7		_a10.1007/978-3-030-16373-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRM267 _b2019 EB
245	0	0	_aPolymyxin antibiotics : _bfrom laboratory bench to bedside _cedited by Jian Li, Roger L. Nation, Keith S. Kaye
250			_aFirst edition
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (VIII, 366 páginas) _b89 ilustraciones, 44 ilustraciones a color
336			_aTexto _btxt _2rdacontent
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1145
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aOverview -- Multidrug resistant Gram-negative pathogens: the urgent need for 'old' polymyxins -- Discovery, antibacterial spectrum and chemistry -- Mechanisms of antibacterial activity -- Mechanisms of resistance -- Bioanalysis and stability of polymyxins -- In vitro pharmacodynamics and PK/PD in animals -- Antibacterial susceptibility breakpoints -- Labeling of parenteral products of colistin methanesulfonate -- Meta-analysis of polymyxin use in patients -- Clinical use of colistin -- Clinical use of polymyxin B -- Pharmacokinetics, pharmacodynamics, toxicodynamics and dosing recommendations -- Rational combinations with other antibiotics -- Toxicities in patients: management and mechanisms -- Antiendotoxin effect -- Discovery of novel polymyxin-like antibiotics -- Conclusion.
520	3		_aThis volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field. It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research. This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative 'superbugs'.
650		7	_aAntibióticos _2embne _9138527
650		7	_aAntiinfecciosos _2embne _9671963
700	1		_aLi, Jian _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aNation, Roger L _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aKaye, Keith S _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030163716
776	0	8	_iPrinted edition: _z9783030163723
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-16373-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b01/2020 _eel _zSI