000			03761nam a2200397 i 4500
988			_aSpringer_BiomedLife_2019
999			_c115915 _d115915 _x1
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003			ESmaUEC
005			20230104140136.0
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008			190724s2019 gw | s |||| 0|eng d
020			_a9783030171483
024	7		_a10.1007/978-3-030-17148-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP632.E4 _b2019 EB
245	0	0	_aEndotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems _cedited by Kevin L. Williams.
250			_a1st ed. 2019.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (XI, 869 páginas) _b 427 ilustraciones, 349 ilustraciones a color
336			_aTexto _btxt _2rdacontent
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aIntroduction -- Section I Pharma -- Historical Perspectives -- Risk, Control and Compliance. -- Sterility and Beyond -- LVPs and SMDs -- Specification Determination -- Static and Dynamic Models (Biodiversity and Heterogeneity) -- Test Development and Validation -- Diminishing Analytics -- Control in Biologics Manufacture -- Depyrogenation and Medical Devices -- Nanoparticles / Problematic Drug Types -- New Frontiers -- Section II Limulus -- Evolution, a Living Fossil and Other Model Arthropods -- Water, Water Everywhere -- Survival and Mass Extinction Events -- Limulus Soup / Hemolymph -- Is Innate Modeling Enough? -- A Foreboding -- Section III Mammalian -- Innate is Inborn -- The Host Response: Fever and Inflammation -- . Parallel Immune Systems: Architecture and Mechanisms -- Structural Change is Functional Change (Hand in Glove) -- Endotoxin and Adjuvanticity in Vaccinology -- Advances in Diagnostics -- The Big S.
520	3		_aEndotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd "living fossil" (Limulus). It is used to detect remnants of the most primitive and destructive forms of life (prokaryotes) as contaminants of complex modern systems (mammalian and Pharma). Recent challenges in the field include those associated with the application of traditional methods to new types of molecules and manufacturing processes. The advent of "at will" production of biologics in lieu of harvesting animal proteins has revolutionized the treatment of disease. While the fruits of the biotechnology revolution are widely acknowledged, the realization of the differences in the means of production and changes in the manner of control of potential impurities and contaminants in regard to the new versus the old are less widely appreciated. Endotoxin as an ancient, dynamic interface between lifeforms, provides a singular perspective from which to view the parallel development of ancient and modern organisms as well as the progress of man in deciphering the complexity of their interactions in his efforts to overcome disease.
650		7	_aEndotoxinas _9671806 _2embne
700	1		_aWilliams, Kevin L _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030171476
776	0	8	_iPrinted edition: _z9783030171490
776	0	8	_iPrinted edition: _z9783030171506
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-17148-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aPRE _cm _dz _feng _ggw _h0 _b01/2020 _ek _zSI