000			03246nam a2200445 i 4500
988			_aSpringer_BiomedLife_2019
999			_c115914 _d115914 _x1
001			115914
003			ESmaUEC
005			20230110040242.0
006			a||||fo|||| 00| 0
007			cr nn nnnaamaa
008			190723s2019 si | s |||| 0|eng d
020			_a9789811373428
024	7		_a10.1007/978-981-13-7342-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC643 _b2019 EB
245	0	0	_aLeukemia stem cells in hematologic malignancies _cedited by Haojian Zhang, Shaoguang Li
250			_aFirst edition
264		1	_aSingapore _bSpringer International Publishing _c2019
300			_a1 recurso en línea (VIII, 229 páginas) _b40 ilustraciones, 37 ilustraciones a color
336			_aTexto _btxt _2rdacontent
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1143
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aRole of leukemia stem cells in pathogenesis of hematologic malignancies -- Leukemia stem cells in chronic myeloid leukemia -- Leukmeia stem cells in MLL-rearranged acute myeloid leukemia -- Interaction between leukmeia stem cells and bone marrow environment -- Molecular signatures of leukemia stem cells -- Metabolic regulation of leukemia stem cell function -- Epigenetic regulation of leukmeia stem cell function -- DNA instability and leukemia stem cell function -- Tumor suppressor genes in leukemia stem cells -- Targeting leukemia stem cells -- Leukemia stem cells and drug resistance -- Hypoxia and leukemia.
520	3		_aThis book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.
650		7	_aLeucemia _2embne _9140673
650		7	_aCélulas madre _2embne _9160528
650		7	_aSangre _2embne _9169169 _xEnfermedades
700	1		_aZhang, Haojian _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aLi, Shaoguang _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9789811373411
776	0	8	_iPrinted edition: _z9789811373435
776	0	8	_iPrinted edition: _z9789811373442
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-7342-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b01/2020 _eel _zSI