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| 988 | _aSpringer_BiomedLife_2019 | ||
| 999 |
_c115842 _d115842 _x1 |
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| 003 | ESmaUEC | ||
| 005 | 20230110040239.0 | ||
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| 007 | cr nn nnnaamaa | ||
| 008 | 190830s2019 si | s |||| 0|eng d | ||
| 020 | _a9789813292673 | ||
| 024 | 7 |
_a10.1007/978-981-32-9267-3 _2doi |
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| 040 |
_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC |
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| 050 | 4 |
_aQH467 _b2019 EB |
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| 100 | 1 |
_aGhosh, Shrestha _eautor _9671853 |
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| 245 | 1 | 0 |
_aSIRT6 Activities in DNA Damage Repair and Premature Aging : _bFunctions of SIRT6 _cby Shrestha Ghosh. |
| 250 | _a1st ed. 2019. | ||
| 264 | 1 |
_aSingapore _bSpringer International Publishing _c2019 |
|
| 300 | _a1 recurso en línea (XLV, 151 páginas) | ||
| 336 |
_aTexto _btxt _2rdacontent |
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| 337 |
_2rdamedia _aelectrónico _bc |
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| 338 |
_2rdacarrier _arecurso electrónico _bcr |
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| 347 |
_atext file _bPDF |
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| 490 | 0 |
_aSpringer Theses Recognizing Outstanding Ph.D. Research _x2190-5053 |
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| 490 | 0 | _aBiomedical and Life Sciences (Springer-11642) | |
| 505 | 0 | _aIntroduction -- Materials and Methods -- Results-I. Lamin A is an endogenous activator of SIRT6 in DNA damage repair process -- Results-II. Haploinsufficiency of p53 rescues lifespan and premature aging-associated abnormalities in Sirt6-deficient mice -- Results-III. SIRT6 is an acetylated protein and a NAD+-dependent self-deacetylase -- Discussion. | |
| 520 | 3 | _aThis book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation etc. Taken together, these studies reveal the various regulatory roles of SIRT6, which are of substantial biological relevance in DNA damage repair, aging and longevity, and can have significant implications in devising therapeutic strategies to combat age-associated pathologies. Given its scope, the book offers a valuable resource for students and researchers in the fields of genetics, cell biology, molecular biology etc. | |
| 650 | 7 |
_aADN _9301511 _2embne _xReplicación |
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| 776 | 0 | 8 |
_iPrinted edition: _z9789813292666 |
| 776 | 0 | 8 |
_iPrinted edition: _z9789813292680 |
| 776 | 0 | 8 |
_iPrinted edition: _z9789813292697 |
| 856 | 4 | 0 |
_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-32-9267-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid) |
| 942 |
_2lcc _cLE |
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| 998 |
_aSI _cm _dz _feng _ggw _h0 _b01/2020 _ek _zSI |
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