000			05182nam a2200445 i 4500
988			_aSpringer_BiomedLife_2019
999			_c115833 _d115833 _x1
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005			20230110040239.0
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008			190826s2019 si | s |||| 0|eng d
020			_a9789811383670
024	7		_a10.1007/978-981-13-8367-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRB147.5 _b2019 EB
245	0	0	_aMitochondria in health and in sickness _cedited by Andrea Urbani, Mohan Babu
250			_aFirst edition
264		1	_aSingapore _bSpringer International Publishing _c2019
300			_a1 recurso en línea (VI, 277 páginas) _b47 ilustraciones, 44 ilustraciones a color
336			_aTexto _btxt _2rdacontent
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1158
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aChapter 1. Mitochondrial Metabolism in Cancer. A Tangled Topic. Which Role for Proteomics? (Roberto Scatena) -- Chapter 2. Mitochondrial Proteins in the Development of Parkinson's Disease (Mauro Fasano and Tiziana Alberio) -- Chapter 3. Role of Mitochondria in Host-Pathogen Interaction (Alessio Soggiu) -- Chapter 4. Mitochondria Lysine Acetylation and Phenotypic Control (Federica Ciregia) -- Chapter 5. Crosstalk Between Oxidative Stress and Mitochondrial Damage: Focus on Amyotrophic Lateral Sclerosis (Viviana Greco) -- Chapter 6. A Tag-Based Affinity Purification Mass Spectrometry Workflow for Systematic Isolation of the Human Mitochondrial Protein Complexes (Zhuoran Wu) -- Chapter 7. Targeted Proteomics to Study Mitochondrial Biology (Rainer Bischoff and Karin Wolters) -- Chapter 8. Recent Advances in Targeting Human Mitochondrial AAA+ Proteases to Develop Novel Cancer Therapeutics (Walid Houry) -- Chapter 9. Investigating the Role of Mitochondria in Type 2 Diabetes - Lessons from Lipidomics and Proteomics Studies of Skeletal Muscle and Liver (Albert Sickmann) -- Chapter 10. Quantification of Mitochondrial Network Characteristics in Health and Disease (Jeff Stuart) -- Chapter 11. Cysteine Switches and the Regulation of Mitochondrial Bioenergetics and ROS Production (Ryan Mailloux) -- Chapter 12. Advances Towards Therapeutic Approaches for mtDNA Disease (Timothy Shutt) -- Chapter 13. Mitochondrial Genetics (Vanessa Goncalves) -- Chapter 14. Heteroplasmy Shifting as Therapy for Mitochondrial Disorders (Neal Sondheimer) -- Chapter 15. Mitochondrial Function and Dysfunction in Alzheimer's Disease (Benedict Albensi) -- Chapter 16. Application of CRISPR-Cas9 Screening Technologies to Study Mitochondrial Biology in Healthy and Disease States (Steven Chan). .
520	3		_aBesides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondria in host-pathogen interactions. Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.
650		7	_aPatología mitocondrial _2embne _9414723
650		7	_aMitocondrias _9147980 _2embne
650		7	_aMetabolismo _xTrastornos _2embne _9168790
700	1		_aUrbani, Andrea _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBabu, Mohan _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9789811383663
776	0	8	_iPrinted edition: _z9789811383687
776	0	8	_iPrinted edition: _z9789811383694
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-8367-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b01/2020 _eel _zSI