000			04943nam a2200409 i 4500
988			_aSpringer_BiomedLife_2019
999			_c115810 _d115810 _x1
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003			ESmaUEC
005			20230110040238.0
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008			190821s2019 gw | s |||| 0|eng d
020			_a9783030231736
024	7		_a10.1007/978-3-030-23173-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH603.G6 _b2019 EB
245	0	4	_aThe Golgi Apparatus and Centriole : _bFunctions, Interactions and Role in Disease _cedited by Malgorzata Kloc.
250			_a1st ed. 2019.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (XIX, 529 páginas) _b 65 ilustraciones, 63 ilustraciones a color
336			_aTexto _btxt _2rdacontent
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aResults and Problems in Cell Differentiation _x0080-1844 _v67
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPart I: Golgi and Centriole Structure, Assembly and Regulation -- Chapter 1: The Evolution of Centriole Structure: Heterochrony, Neoteny, and Hypermorphosis -- Chapter 2: The role of protein acetylation in centrosome biology -- Chapter 3: Formins, Golgi and the centriole -- Chapter 4: Role of intracellular transport in the centriole-dependent formation of Golgi ribbon -- Chapter 5: RhoA pathway and actin regulation of the Golgi/centriole complex -- Chapter 6: Multiple roles of Rab GTPases at the Golgi -- Part II: Golgi and Centriole Positioning, Interactions andDynamics -- Chapter 7: Positioning of the Centrosome and Golgi Complex -- Chapter 8: Centriole positioning: not just a little dot in the cell -- Chapter 9: The MTOC/Golgi complex at the T cell immunological synapse -- Chapter 10: Semi-intact cell system for reconstituting and analyzing cellular Golgi dynamics -- Part III: Role of Centriole and Golgi in the Organization of Cell, Embryo and OrganGeometry -- Chapter 11: The centrosome as a geometry organizer -- Chapter 12: Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster -- Chapter 13: Centrosomes in branching morphogenesis -- Chapter 14: MTOC organization and competition during neuron differentiation -- Chapter 15: The Golgi apparatus in polarized neuroepithelial stem cells and their progeny: canonical and non-canonical features -- Chapter 16: Communication of the cell periphery with the Golgi apparatus - a hypothesis -- Part IV: Golgi- and Centriole- related diseases -- Chapter 17: Breaking Bad: Uncoupling of Modularity in Centriole Biogenesis and the Generation of Excess Centrioles in Cancer -- Chapter 18: Centrosome amplification and tumorigenesis - cause or effect? -- Chapter 19: Golgi structure and function in health, stress and diseases -- Chapter 20: Selected Golgi-localized proteins and carcinogenesis - what do we know?.
520	3		_aThis volume takes a closer look how the cell organelles Golgi apparatus (also known as the Golgi complex or Golgi body), and centriole are structurally and functionally intertwined. Initially, it was believed that the role of Golgi complex is limited to the packaging and preparation for secretion of various cellular proteins, while the centriole participates in cell division and cilia formation. However, since their discovery nearly 200 years ago, it became clear that these two organelles are interacting, and that their functions are much more complex and far reaching than previously thought. Recent findings indicate that the Golgi-Centriole relationship may be important for directional protein transport, cell polarization and cell cycle progression. Current studies indicate that Golgi and centriole also participate in development and act as cellular and immunological sensors, and that their abnormalities lead to cell and developmental abnormalities, Alzheimer, cancer, various lipid disorders and neurological and immunological diseases in humans. This volume combines the latest information on the structure, molecular composition, and roles of Golgi and centriole in various cellular functions and diseases. The better understanding of the Golgi-centriole interactions may lead to the development of novel therapies for the treatment of various diseases, including cancer. .
650		7	_2embne _9671792 _aAparato de Golgi
700	1		_aKloc, Malgorzata _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030231729
776	0	8	_iPrinted edition: _z9783030231743
776	0	8	_iPrinted edition: _z9783030231750
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-23173-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b01/2020 _ek _zSI