000			05247nam a2200409 i 4500
988			_aSpringer_BiomedLife_2019
999			_c115804 _d115804 _x1
001			115804
003			ESmaUEC
005			20230104140106.0
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007			cr nn nnnaamaa
008			190909s2019 gw | s |||| 0|eng d
020			_a9783030220945
024	7		_a10.1007/978-3-030-22094-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC582 _b2019 EB
245	0	0	_aCytokine Storm Syndrome _cedited by Randy Q. Cron, Edward M. Behrens.
250			_a1st ed. 2019.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (XXI, 617 páginas) _b 31 ilustraciones, 25 ilustraciones a color
336			_aTexto _btxt _2rdacontent
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPart I: Background -- 1. Cytokines in Cytokine Storm Syndrome -- 2. History of hemophagocytic lymphohistiocytosis -- 3.The History of Macrophage Activation Syndrome in Autoimmune Diseases -- 4. Clinical Features of Cytokine Storm Syndrome -- 5. Laboratory Features and Pathology of the Cytokine Storm Syndromes -- 6. Criteria for Cytokine Storm Syndromes -- Part II: Genetics of Cytokine Storm Syndromes -- 7.Genetics of Acquired Cytokine Storm Syndromes -- 8. Genetics of Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis -- Part III: Immunology of Cytokine Storm Syndromes -- 9. CD8+ T cell biology in cytokine storm syndromes -- 10. Immunology of Cytokine Storm Syndromes: Natural Killer Cells -- 11. Myeloid cells in the immunopathogenesis of cytokine storm syndromes -- 12. Cytokines in Cytokine Storm Syndrome -- 13. Primary Immunodeficiencies and Cytokine Storm Syndromes -- Part IV: Infectious Triggers of Cytokine Storm Syndromes -- 14. Infectious Triggers of Cytokine Storm Syndromes: Herpes Virus Family (non-EBV) -- 15. Cytokine Storm Syndromes Associated with Epstein Barr Virus -- 16. Cytokine Storm Syndrome Associated with Hemorrhagic Fever and Other Viruses -- 17. Cytokine Storm Syndrome as a manifestation of Primary HIV Infection -- 18. Bacteria-Associated Cytokine Storm Syndrome -- 19. Zoonotic Bacterial Infections Triggering Cytokine Storm Syndrome -- 20. Parasitic and Fungal Triggers -- Part V: Rheumatic Triggers of Cytokine Storm Syndromes -- 21. Cytokine Storm Syndrome associated with Systemic Juvenile Idiopathic Arthritis -- 22. Systemic Lupus Erythematosus and Cytokine Storm -- 23. Kawasaki Disease -- 24. The Intersections of Autoinflammation and Cytokine Storm -- 25. Macrophage Activation Syndrome in the Setting of Rheumatic Diseases -- Part VI: Other Triggers of Cytokine Storm Syndromes -- 26. Hemophagocytic lymphohistiocytosis in the context of hematological malignancies and solid tumors -- 27. Cytokine Storm and Sepsis induced Multiple Organ Dysfunction Syndrome -- Part VII: Murine Models of Cytokine Storm Syndrom -- 28. Murine Models of Familial Cytokine Storm Syndromes -- 29. Murine Models of Secondary Cytokine Storm Syndromes -- Part VIII: Therapy of Cytokine Storm Syndromes -- 30. Etoposide Therapy of Cytokine Storm Syndromes -- 31. IL-1 Family Blockade -- 32. IL-6 Blockade -- 33. Alternative Therapies for Cytokine Storm Syndromes -- 34. Salvage Therapy and Allogeneic Hematopoietic Cell Transplantation for the Severe Cytokine Storm Syndrome of Hemophagocytic Lymphohistiocytosis.
520	3		_aCytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder - from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.
650		7	_2embne _9142010 _aEnfermedades inmunológicas
700	1		_aCron, Randy Q _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBehrens, Edward M _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030220938
776	0	8	_iPrinted edition: _z9783030220952
776	0	8	_iPrinted edition: _z9783030220969
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-22094-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b12/2019 _eIG _zSI