000			03058nam a2200421 i 4500
988			_aSpringer_BiomedLife_2019
999			_c115798 _d115798 _x1
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005			20230110040238.0
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008			190831s2019 gw | s |||| 0|eng d
020			_a9783030214548
024	7		_a10.1007/978-3-030-21454-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP552.C22 _b2019 EB
245	0	0	_aCalcitonin Gene-Related Peptide (CGRP) Mechanisms : _bFocus on Migraine _cedited by Susan D. Brain, Pierangelo Geppetti.
250			_a1st ed. 2019.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (VII, 192 páginas) _b 23 ilustraciones, 17 ilustraciones a color
336			_aTexto _btxt _2rdacontent
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aHandbook of Experimental Pharmacology _x0171-2004 _v255
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_a1. CGRP Discovery and Timeline -- 2. CGRP Receptor Biology: Is There More Than One Receptor? -- 3. The Structure of the CGRP and Related Receptors -- 4. CGRP Receptor Signalling Pathways -- 5. Pathways of CGRP Release from Primary Sensory Neurons -- 6. CGRP in Animal Models of Migraine -- 7. CGRP in Human Models of Migraine -- 8. Role of CGRP in Migraine -- 9. Understanding CGRP and Cardiovascular Risk -- 10. CGRP and Painful Pathologies other than Headache -- 11. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.
520	3		_aThis book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention. .
650		7	_9671768 _aCalcitonina _2embne
700	1		_aBrain, Susan D _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aGeppetti, Pierangelo _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt _995172
776	0	8	_iPrinted edition: _z9783030214531
776	0	8	_iPrinted edition: _z9783030214555
776	0	8	_iPrinted edition: _z9783030214562
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-21454-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b12/2019 _eIG _zSI