000			03524nam a2200409 c 4500
988			_aSpringer_BiomedLife_2019
999			_c115553 _d115553 _x1
001			115553
003			ESmaUEC
005			20230110040236.0
006			a||||fo|||| 00| 0
007			cr nn nnnaamaa
008			190614s2019 gw a o |||| 0|eng d
020			_a9783030127343
024	7		_a10.1007/978-3-030-12734-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRA645.C3 _b2019 EB
245	0	0	_aHypoxia and Cancer Metastasis _cedited by Daniele M. Gilkes.
250			_a1st ed. 2019.
264		1	_aCham _bSpringer International Publishing _c2019
300			_a1 recurso en línea (VIII, 160 páginas) _b 17 ilustraciones, 16 ilustraciones a color
336			_aTexto _btxt _2rdacontent
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1136
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPreface -- Hypoxia mediates tumor malignancy -- Clinical methods for quanitifying hypoxia in human tumors -- Hypoxia-induced phenotypes that mediate tumor heterogeneity -- Hypoxia and the tumors secretome -- Hypoxic signaling in angiogenesis and lymphangiogenesis -- Hypoxia induced metabolic reprogramming in cancer metastasis -- The metastatic niche and hypoxia -- Hypoxia and immune suppression -- Hypoxia-induced resistance to cancer therapy -- Therapeutic stratagies to target the hypoxic microenvironment -- Index. .
520	3		_aThe present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.
650		7	_2embne _9139308 _aCáncer
700	1		_aGilkes, Daniele M _eeditor
776	0	8	_iPrinted edition: _z9783030127336
776	0	8	_iPrinted edition: _z9783030127350
776	0	8	_iPrinted edition: _z9783030127367
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-12734-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b12/2019 _ek _zSI