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710	2		_aSpringerLink (Online service) _9106996
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008			190606s2019 gw a o |||| 0|eng d
020			_a9783030151119
024	7		_a10.1007/978-3-030-15111-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH529 _b2019 EB
100	1		_aSwynghedauw, Bernard _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9671625
245	1	4	_aThe Biology of Senescence : _bA Translational Approach _cby Bernard Swynghedauw.
250			_a1st ed. 2019.
264		1	_aCham _bSpringer International Publishing _c2019.
300			_a1 recurso en línea (XI, 121 páginas) _b 23 ilustraciones, 13 ilustraciones a color.
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aPractical Issues in Geriatrics _x2509-6060
490	0		_aMedicine (Springer-11650)
505	0		_a1. Introduction -- 2. The emerging medical landscape -- 3. Origins of ageing -- 4. The senescent cell -- 5. « Benign » clinical manifestations and their relationships with the senescent cell -- 6. Age-linked non transmissible diseases -- 7. The senescent cardiovascular system -- 8. « To treat» or prevent ageing -- 9. Senescence and darwinian evolution -- 10. Conclusions -- 11. Summary -- 12. Annexes -- 13. References.
520	3		_aThis book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for "treating" it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related "chronic non-transmissible diseases"), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to "treat" or "prevent" the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.
988			_aSpringer_Medicine_2019
650		7	_9141231 _aEnvejecimiento _2embne
776	0	8	_iPrinted edition: _z9783030151102
776	0	8	_iPrinted edition: _z9783030151126
776	0	8	_iPrinted edition: _z9783030151133
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-15111-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b11/2019 _ea _zSI