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008			190301s2019 gw a o |||| 0|eng d
020			_a9783030050672
024	7		_a10.1007/978-3-030-05067-2 _2doi
040			_bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC268.4 _b2019 EB
245	0	4	_aThe Unfolded Protein Response in Cancer _cedited by Robert Clarke
264		1	_aCham _bSpringer International Publishing _c2019
300			_a1 recurso en línea (XI, 220 páginas) _b15 ilustraciones, 14 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aCancer Drug Discovery and Development _x2196-9906
490	0		_aMedicine (Springer-11650)
505	0		_aIntroduction: The Unfolded Protein Response -- Endoplasmic Reticulum Stress Signaling During Development -- Regulation of the Unfolded Protein Response and its Roles in Tumorigenesis and Cancer Therapy -- ATF4, Hypoxia and Treatment Resistance in Cancer -- Role of Protein Translation in the Unfolded Protein Response -- Roles of Spliced and Unspliced XBP1 in Breast Cancer -- The Unfolded Protein Response in Triple-Negative Breast Cancer -- The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer -- Outside the Endoplasmic Reticulum: Non-Canonical GRP78 Signaling -- Autophagy and the Unfolded Protein Response in Neurodegenerative Diseases -- Index.
520	3		_aThis volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.
988			_aSpringer_Medicine_2019
650		7	_aCáncer _2embne _9273952 _xAspectos genéticos
700	1		_aClarke, Robert. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service) _9106996
776	0	8	_iPrinted edition: _z9783030050658
776	0	8	_iPrinted edition: _z9783030050665
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-05067-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_dz _feng _ggw _h0 _b02/2023 _eb _zSI