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008			190104s2019 gw a o |||| 0|eng d
020			_a9783030029616
024	7		_a10.1007/978-3-030-02961-6 _2doi
040			_bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP572 .I5 _b2019 EB
245	0	0	_aCongenital Hyperinsulinism : _bA Practical Guide to Diagnosis and Management _cedited by Diva D. De León-Crutchlow, Charles A. Stanley
264		1	_aCham _bSpringer International Publishing : _bImprint: Humana Press _c2019
300			_a1 recurso en línea (XV, 165 páginas 22 ilustraciones, 12 ilustraciones a color)
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	1		_aContemporary Endocrinology, _x2523-3785
490	0		_aMedicine (Springer-11650)
505	0		_aApproach to the Diagnosis of Neonates and Infants with Persistent Hypoglycemia -- Diazoxide-Responsive Forms of Congenital Hyperinsulinism -- Diazoxide-Unresponsive Forms of Congenital Hyperinsulinism -- Syndromic Causes of Congenital Hyperinsulinism -- Molecular Diagnosis of Congenital Hyperinsulinism -- Medical Management of Hyperinsulinism -- 18F-DOPA PET -- Histopathology of the Pancreas in Congenital Hyperinsulinism -- Surgery for Congenital Hyperinsulinism -- Perioperative Management of Hyperinsulinism -- Management of the Child with Persistent Hypoglycemia After Surgery -- Management of Diabetes and Pancreatic Insufficiency after Pancreatectomy -- Feeding Problems in Congenital Hyperinsulinism -- Neurodevelopmental Outcomes.
520	3		_aThis unique book is a practical guide for the clinician faced with the challenge of diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI), within the framework of pathophysiology and molecular genetics. Major advances have been made in HI research over the past two decades, and with this better understanding of the molecular genetics of HI, a "personalized" approach to management according to the type of hyperinsulinism, and particularly according to the likelihood of focal hyperinsulinism, is starting to emerge. The opening chapter discusses HI diagnosis using biochemical approaches and phenotype characterization. The various forms of HI are then presented in detail in three main categories: diazoxide-responsive, diazoxide-unresponsive and syndromic HI. Both medical and surgical management strategies are then discussed, covering imaging, histology, surgical approach, and post-operative management. Complications, such as feeding problems, and long-term outcomes, such as neurodevelopmental issues, are carefully considered in the final chapter. Practical and user-friendly, Congenital Hyperinsulinism is the go-to resource for pediatric endocrinologists, residents and fellows, general pediatricians and neonatologists.
988			_aSpringer_Medicine_2019
650		7	_aInsulina _2embne _9670146
650		7	_aDiabetes _9138582 _2embne
650		7	_aDiabetes en niños _9670147
700	1		_aDe León-Crutchlow, Diva D. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aStanley, Charles A. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030029609
776	0	8	_iPrinted edition: _z9783030029623
830		0	_aContemporary Endocrinology, _x2523-3785
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-02961-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_dz _feng _ggw _h0 _b07/2019 _eh _zSI