000			04036nam a2200457 i 4500
003			ESmaUEC
006			a||||fo|||| 00| 0
007			cr nn nnnaamaa
040			_aES-MaUEC _bspa _cES-MaUEC
336			_aTexto _btxt _2rdacontent
710	2		_aSpringerLink (Online service) _9106996
999			_c109372 _d109372 _x1
001			109372
005			20230102113413.0
008			190604s2019 gw | o |||| 0|eng d
020			_a9783030166243
024	7		_a10.1007/978-3-030-16624-3 _2doi
050		4	_aQH588.S83 _b2019 EB
245	0	0	_aCancer Stem Cell Resistance to Targeted Therapy _cedited by Cristina Maccalli, Matilde Todaro, Soldano Ferrone.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (XIX, 256 páginas) _b21 ilustraciones a color
337			_aelectrónico _bc
338			_arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
490	0		_aResistance to Targeted Anti-Cancer Therapeutics _x2196-5501 _v19
505	0		_aCancer Stem Cells: from birth to death -- A Cancer Stem Cell Perspective on Minimal Residual Disease in Solid Malignancies -- Cancer Stem Cells in Lung Cancer: Roots of Drug Resistance and Targets for Novel Therapeutic Strategies -- Overexpression of YY1 Regulates the Resistance of Cancer Stem Cells: Targeting YY1 -- Cancer Stem Cell Challenges in Melanoma Characterization and Treatment -- Harnessing the immune system to target cancer cells -- Targeting leukemia stem cells and the immunological bone marrow microenvironment -- Crosstalk Between Prostate Cancer Stem Cells and Immune Cells: Implications for Tumor Progression and Resistance to Immunotherapy -- Cancer stem cells: the players of immune evasion from immunotherapy -- Index.
520	3		_aThis book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.
988			_aPrimersemestre_2019_BiomedLife
650		7	_2embne _aCélulas madre _9160528
650		7	_2embne _aInmunología _9138330
650		7	_2embne _aOncología _9139207
700	1		_aFerrone, Soldano. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aMaccalli, Cristina. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aTodaro, Matilde. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030166236
776	0	8	_iPrinted edition: _z9783030166250
776	0	8	_iPrinted edition: _z9783030166267
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-16624-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b08/2019 _ek _zSI