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336			_aTexto _btxt _2rdacontent
710	2		_aSpringerLink (Online service) _9106996
999			_c109334 _d109334 _x1
001			109334
005			20230102113411.0
008			190325s2019 si | o |||| 0|eng d
020			_a9789811361869
024	7		_a10.1007/978-981-13-6186-9 _2doi
050		4	_aQP551 _b2019 EB
245	0	0	_aProgranulin and Central Nervous System Disorders _cedited by Hideaki Hara, Masato Hosokawa, Shinsuke Nakamura, Takayoshi Shimohata, Masugi Nishihara.
264		1	_aSingapore _bSpringer International Publishing _c2019
300			_a1 recurso en línea (VII, 183 páginas) _b37 ilustraciones, 13 ilustraciones a color
337			_aelectrónico _bc
338			_arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aChapter 1. Molecular and Functional Properties of Progranulin -- Chapter 2. Progranulin as a biomarker for neurodegenerative diseases -- Chapter 3. PGRN and FTLD -- Chapter 4. PGRN and neurodegenerative diseases other than FTLD -- Chapter 5. Progranulin Regulations of Lysosomal Homeostasis and its Involvement in Neurodegenerative Diseases -- Chapter 6. Molecular and Functional Properties of Progranulin -- Chapter 7. PGRN and neuroinflammation -- Chapter 8. Neural Stem/Progenitor Cells and Progranulin -- Chapter 9. Generation and phenotyping of progranulin-deficient mice -- Chapter 10. Pleiotropic protective effects of progranulin in the treatment of ischemic stroke -- Chapter 11. New therapeutic approaches against ocular diseases.
520	3		_aThis book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.
988			_aPrimersemestre_2019_BiomedLife
650		7	_2embne _aProteínas _9139861
650		7	_2embne _9670257 _aGlucoproteínas
650		7	_2embne _9161615 _aNeurogenética
700	1		_aHara, Hideaki. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aHosokawa, Masato. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aNakamura, Shinsuke. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aNishihara, Masugi. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aShimohata, Takayoshi. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9789811361852
776	0	8	_iPrinted edition: _z9789811361876
776	0	8	_iPrinted edition: _z9789811361883
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-6186-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b08/2019 _ek _zSI