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003			ESmaUEC
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040			_aES-MaUEC _bspa _cES-MaUEC
336			_aTexto _btxt _2rdacontent
988			_aSpringerBiomedLife_2019
999			_c109290 _d109290 _x1
001			109290
005			20230104141449.0
008			190528s2019 gw | o |||| 0|eng d
020			_a9783319993751
024	7		_a10.1007/978-3-319-99375-1 _2doi
050		4	_aQP182 _b2019 EB
245	0	0	_aHandbook of Immunosenescence : _bBasic Understanding and Clinical Implications _cedited by Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec.
250			_a2nd ed. 2019.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (272 ilustraciones, 161 ilustraciones a color. eReference)
337			_aelectrónico _bc
338			_arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aMethods and Models for Studying Immunosenescence -- Methods for studying human immunosenescence in tissues other than blood -- Mechanisms - Receptors and Signal Transduction -- Clinical Relevance in Disease States - Infection -- Modulation -- Nutrition.
520	3		_aImmunosenescence is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question "can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?".
650		7	_2embne _aInmunología _9138330
700	1		_aFranceschi, Claudio. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aFulop, Tamas. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aHirokawa, Katsuiku. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aPawelec, Graham. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783319993737
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi-org/10.1007/978-3-319-99375-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b07/2019 _ek _zSI