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040			_aES-MaUEC _bspa _cES-MaUEC
336			_aTexto _btxt _2rdacontent
988			_aSpringerBiomedLife_2019
999			_c109288 _d109288 _x1
001			109288
005			20230104141448.0
008			190528s2019 gw | o |||| 0|eng d
020			_a9783030178642
024	7		_a10.1007/978-3-030-17864-2 _2doi
050		4	_aRC268.3 _b2019 EB
100	1		_aGarrido, Federico _eautor _9670178
245	1	0	_aMHC Class-I Loss and Cancer Immune Escape _cby Federico Garrido.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (X, 101 páginas) _b41 ilustraciones, 38 ilustraciones a color
337			_aelectrónico _bc
338			_arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1151
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPreface -- Introduction -- Mhc/Hla Class I Loss In Cancer Cells -- Hla Class-I Expression And Cancer Immunotherapy -- Hla Class-Ii Expression In Human Tumors -- Index.
520	3		_aThis book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the "Antigen Presenting Molecules" and the "T Lymphocytes". The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between "self and non self". Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism. Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types of tumors: lung, prostate, bladder and breast...ect. as well as melanoma and lymphoma. This book will be useful to Oncologists, Pathologists and Immunologist that will enter this fascinating area of research. It will be also interesting for biologist, doctoral students and medical residents interested in "Tumor Immunology". .
650		7	_2embne _9195595 _aCáncer _xAspectos inmunológicos
776	0	8	_iPrinted edition: _z9783030178635
776	0	8	_iPrinted edition: _z9783030178659
776	0	8	_iPrinted edition: _z9783030178666
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi-org/10.1007/978-3-030-17864-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b07/2019 _ek _zSI