000			04038nam a2200421 i 4500
003			ESmaUEC
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040			_aES-MaUEC _bspa _cES-MaUEC
336			_aTexto _btxt _2rdacontent
988			_aSpringerBiomedLife_2019
999			_c109282 _d109282 _x1
001			109282
005			20230110040218.0
008			190528s2019 gw | o |||| 0|eng d
020			_a9783030114886
024	7		_a10.1007/978-3-030-11488-6 _2doi
050		4	_aQP751 _b2019 EB
245	0	0	_aBioactive Lipids in Health and Disease _cedited by Andres Trostchansky, Homero Rubbo.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (VIII, 198 páginas) _b41 ilustraciones, 35 ilustraciones a color
337			_aelectrónico _bc
338			_arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1127
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPrelims -- Diffusion and transport of reactive species across cell membranes -- Characterization of hydroxy and hydroperoxy polyunsaturated fatty acids by mass spectrometry. Understanding Peroxisome Proliferator-Activated Receptors: from the structure to the regulatory actions on metabolism -- Diminishing Inflammation by Reducing Oxidant Generation: Nitrated Fatty Acid-Mediated Inactivation of Xanthine Oxidoreductase. Unfolded protein response: Cause or consequence of lipid and lipoprotein metabolism disturbances?- Arachidonic acid metabolism in macrophages: role of NADPH oxidases -- Lipid Metabolism and Signaling in Platelet Function -- Dyslipidemia in ischemia/reperfusion injury -- Epicardial adipose tissue in cardiovascular disease -- Bioactive Lipids and the gut-brain axis: diet as a modulator of bioactivity and diversity of lipids in the brain -- Nitroalkylation of α-synuclein by nitro-oleic acid: Implications for Parkinson´s disease -- Bioactive lipids in inflammation after central nervous system injury -- Index.
520	3		_aThe purpose of this book is to introduce the readers on the perspective of the role that unsaturated fatty acids and complex lipids play on health and disease. Bioactive lipids can be modified affecting membrane composition, structure and fluidity in addition to changes in cell signaling associated to lipid-protein (membrane receptors) interactions, issues that are addressed by the authors. This book analyzes key topics involving bioactive lipids and their role in normal signaling and the mechanisms of disease. The book navigates from structural studies of oxidized and non-oxidized lipids to the reactions and cell signaling processes that bioactive lipids play in cardiovascular and neurodegenerative diseases. The book contains the recent advances reported in the literature about lipidomics as well as the role that lipid-derived compounds exert on unfolded protein response and lipid metabolism and disease. This book represents a state of the art introduction to lipid metabolism from a biochemical to an in vivo overview being an useful tool for students and investigators. We hope the mechanistic observations on the role of bioactive lipids in health and disease serve a perspective to improve the existing treatments or propose new lipid-based pharmacology.
650		7	_2embne _aLípidos _9142933
650		7	_2embne _aFisiología humana _9140024
650		7	_2embne _aGenética humana _9140562
700	1		_aRubbo, Homero. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aTrostchansky, Andres. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030114879
776	0	8	_iPrinted edition: _z9783030114893
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi-org/10.1007/978-3-030-11488-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b07/2019 _ek _zSI