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336			_aTexto _btxt _2rdacontent
988			_aSpringerBiomedLife_2019
999			_c109215 _d109215 _x1
001			109215
005			20230110040215.0
008			190116s2019 gw | s |||| 0|eng d
020			_a9783030042783
024	7		_a10.1007/978-3-030-04278-3 _2doi
050		4	_aQP752.C5 _b2019 EB
245	0	0	_aCholesterol Modulation of Protein Function : _bSterol Specificity and Indirect Mechanisms _cedited by Avia Rosenhouse-Dantsker, Anna N. Bukiya.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (X, 197 páginas) _b45 ilustraciones, 33 ilustraciones a color
337			_aelectrónico _bc
338			_arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1115
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPart 1. Sterol specificity in modulating protein function: 1. Chirality effect on cholesterol modulation of protein function -- 2. A critical analysis of molecular mechanisms underlying membrane cholesterol sensitivity of GPCRs -- 3. Regulation of BK channel activity by cholesterol and its derivatives -- 4. Chiral specificity of cholesterol orientation within cholesterol binding sites in inwardly rectifying potassium channels -- Part 2. Indirect modulation of protein function by cholesterol: 5. Cholesterol effect on the physical properties of lipid membranes -- 6. Effect of cholesterol on the dipole potential of lipid membranes -- 7. Mass spectroscopy imaging of cholesterol -- 8. Cholesterol-dependent gating effects on ion channels.
520	3		_aIn this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed. This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions. In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function. The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
650		7	_2embne _9139711 _aColesterol
650		7	_2embne _aMembranas celulares _9142266
650		7	_2embne _9155847 _aCanales iónicos
700	1		_aBukiya, Anna N. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aRosenhouse-Dantsker, Avia. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030042776
776	0	8	_iPrinted edition: _z9783030042790
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi-org/10.1007/978-3-030-04278-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b07/2019 _ek _zSI