000			03404nam a2200385 c 4500
988			_aSpringerBiomedLife_2019
999			_c109209 _d109209 _x1
001			109209
003			ESmaUEC
005			20230110040215.0
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007			cr nn nnnaamaa
008			190521s2019 si | s |||| 0|eng d
020			_a9789811367861
024	7		_a10.1007/978-981-13-6786-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aRS380 _b2019 EB
100	1		_aKawashima, Yoshiaki _eautor _9669982
245	1	0	_aSpherical Crystallization as a New Platform for Particle Design Engineering _cby Yoshiaki Kawashima.
264		1	_aSingapore _bSpringer International Publishing _c2019
300			_a1 recurso en línea (XVII, 118 páginas) _b110 ilustraciones, 32 ilustraciones a color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc
338			_arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aIntroduction -- Concept of spherical crystallization -- Paradigm shifted pharmaceutical process introduced by spherical crystallization -- Particulate-design platform developed by the Advanced Spherical Crystallization System -- Development of Novel Microsphere and Microballoon DDS by Polymeric Spherical Crystallization -- Development of PLGA Nanopsphere for Drug Delivery System (DDS) Prepared by Polymeric Spherical Crystallization -- Application of PLGA NSs to cosmetics -- Future perspectives of PLGA nanospheres for advanced DDSs and continuous preparation systems for spherical crystallizers.
520	3		_aThis book describes the principles and applications of the spherical crystallization technique, from the standpoint of its inventor. After an introduction on the history of particle design engineering and nanotechnology, the concept of spherical crystallization itself is clearly explained. Attention then turns to the application of spherical crystallization in pharmaceutical processes. It is explained how the technique can provide physicochemical properties suitable for direct tableting of active pharmaceutical ingredients and how it has enabled the development of a novel particulate design platform from single to complex system. Subsequent chapters describe the roles of polymeric spherical crystallization in the preparation of novel microspheres, microballoons for drug delivery systems (DDS) and the development of biocompatible and biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanospheres. The various applications of PLGA nanospheres composite within oral-, pulmonary-, transdermal DDS and cosmetics are fully discussed. Finally, future perspectives are presented on use of the technology in the design and industrial-scale manufacture of new drug delivery systems, highlighting how a continuous pharmaceutical process that meets US Food and Drug Administration quality requirements should soon be introduced.
650		7	_2embne _9155839 _aBiotecnología farmacéutica
776	0	8	_iPrinted edition: _z9789811367854
776	0	8	_iPrinted edition: _z9789811367878
776	0	8	_iPrinted edition: _z9789811367885
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi-org/10.1007/978-981-13-6786-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _cm _dz _feng _ggw _h0 _b07/2019 _ek