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040			_aES-MaUEC _bspa _cES-MaUEC
336			_aTexto _btxt _2rdacontent
988			_aSpringerBiomedLife_2019
999			_c109197 _d109197 _x1
001			109197
005			20230110040214.0
008			190411s2019 gw |a o |||| 0|eng d
020			_a9783030120405
024	7		_a10.1007/978-3-030-12040-5 _2doi
050		4	_aQR185.8.T2 _b2019 EB
245	0	0	_aThymus Transcriptome and Cell Biology _cedited by Geraldo A. Passos
264		1	_aCham, Switzerland _bSpringer International Publishing _c2019
300			_a1 recurso en línea (XVII, 318 páginas) _b30 ilustraciones, 23 ilustraciones a color
337			_aelectrónico _bc
338			_arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_a1. History of the thymus: From a vestigial organ to the programming of immunological self-tolerance -- 2. Thymus Ontogeny and Development -- 3. The Ins and Outs of Thymic Epithelial Cell Differentiation and Function -- 4. T-Cell Development: From T-Lineage Specification to Intrathymic Maturation -- 5. Intrathymic cell migration: implications in thymocyte development and T-cell repertoire formation -- 6. Thymic crosstalk: an overview of the complex cellular interactions that control the establishment of T-cell tolerance -- 7. The Autoimmune Regulator (AIRE) gene, the master activator of self-antigen expression in the thymus -- 8. Aire Mutations and Autoimmune Diseases -- 9. The thymus as a mirror of the body's gene expression -- 10. Functional genomics of the infant human thymus: Aire and minipuberty -- 11. Thymus transcriptome of TGF-β superfamily -- 12. Development of thymic regulatory T lymphocytes -- 13. Adding insult to injury: improving the regenerative capacity of the aged thymus following clinically induced damage -- 14. Thymus rejuvenation after autologous hematopoietic stem cell transplantation in patients with autoimmune diseases.
520	3		_aThis volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases.
650		7	_2embne _aLinfocitos T _9144344
650		7	_2embne _aEndocrinología _9139372
700	1		_aPassos, Geraldo A. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _986874
776	0	8	_iPrinted edition: _z9783030120399
776	0	8	_iPrinted edition: _z9783030120412
776	0	8	_iPrinted edition: _z9783030120429
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi-org/10.1007/978-3-030-12040-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_cm _dz _feng _ggw _h0 _b07/2019 _ek _zSI