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001			107948
003			DE-He213
005			20230102113328.0
007			cr nn 008mamaa
008			180425s2018 gw | s |||| 0|eng d
020			_a9783319642574 _9
024	7		_a10.1007/978-3-319-64257-4 _2doi
050		4	_aRC643 2018 EB
245	1	0	_aAcute Promyelocytic Leukemia : _bA Clinical Guide _cedited by Oussama Abla, Francesco Lo Coco, Miguel A. Sanz.
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2018.
300			_a1 recurso en línea ( XII, 274 páginas 39 ilustraciones, 29 ilustraciones a color)
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF _2rda
505	0		_aHistory of APL -- Molecular Targets of Treatment in APL -- The Leukemic Stem Cell -- The Molecular Genetics of APL -- APL Coagulopathy -- Early Death in APL -- Prognostic Factors in APL -- First-line therapy for APL: Chemotherapy-based approach -- First-line Therapy: ATRA-ATO/Reduced Chemotherapy Approach -- Cure of APL without Chemotherapy -- Minimal Residual Disease in APL -- Treatment of refractory and relapsed APL -- Hematopoietic Stem Cell Transplantation in APL -- APL in Children -- Management of APL in the Elderly -- Special Situations in APL -- APL in Developing Countries: A Chemotherapy-Based Approach -- APL in Developing Countries: ATO based Approach -- Therapy-Related APL -- Rare Acute Leukemia Variants involving Retinoic Acid Receptor Genes -- Management of Treatment-Related Complications in APL.
520			_aThis book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges. Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.
650		7	_aLeucemia _2embne _9140673
700	1		_aAbla, Oussama _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2009182367 _1http://viaf.org/viaf/7091154441753935460001
700	1		_aLo Coco, Francesco _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2018186600 _1http://viaf.org/viaf/311362416
700	1		_aSanz, Miguel A _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _1http://viaf.org/viaf/316019917
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iPrinted edition: _z9783319642567
776	0	8	_iPrinted edition: _z9783319642581
776	0	8	_iPrinted edition: _z9783030097134
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-64257-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490			_aMedicine (Springer-11650)
988			_aSpringer_Medicine_2018
998			_aSI _b06/2019 _cm _dz _ea _feng _ggw _h0
999			_c107948 _d107948 _x1