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020 _a9783319789576
_9
024 7 _a10.1007/978-3-319-78957-6
_2doi
050 4 _aRB155.8 2018 EB
040 _aES-MaUEC
_bspa
245 1 0 _aGene Therapy in Reconstructive and Regenerative Surgery
_cedited by Giorgio Giatsidis.
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Springer
_c2018.
300 _a1 recurso en línea ( VII, 113 páginas 8 ilustraciones, 7 ilustraciones a color)
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
_2rda
505 0 _aPrinciples of Gene Therapy in Reconstructive and Regenerative Surgery -- Gene Therapy in Skin and Wound Healing -- Gene Therapy in Pathologic Scars -- Gene Therapy in Skeletal Muscle Repair and Regeneration -- Gene Therapy in Cartilage Repair and Regeneration -- Gene Therapy in Tendon Repair and Regeneration -- Gene Therapy and Free Flaps for Therapeutic Reconstructive Surgery -- Developing a Gene Therapy Clinical Trial: Tips and Tricks -- Future Directions in Reconstructive and Regenerative Surgery.
520 _aThis book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions. Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided. Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants. Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.
650 7 _aTerapia genética
_2embne
_9150702
700 1 _aGiatsidis, Giorgio
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
_0http://id.loc.gov/authorities/names/no2005046756
_1http://viaf.org/viaf/148105729
_9106996
776 0 8 _iPrinted edition:
_z9783319789569
776 0 8 _iPrinted edition:
_z9783319789583
776 0 8 _iPrinted edition:
_z9783030076894
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-78957-6
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490 _aMedicine (Springer-11650)
988 _aSpringer_Medicine_2018
998 _aSI
_a_alco
_a_vill
_b06/2019
_cm
_dz
_ef
_feng
_ggw
_h0
999 _c107867
_d107867
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