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336			_aTexto _btxt _2rdacontent
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
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020			_a9789811319129
024	7		_a10.1007/978-981-13-1912-9 _2doi
050		4	_aRS380 _b2018 EB
245	0	0	_aSynthesis of Therapeutic Oligonucleotides _cedited by Satoshi Obika, Mitsuo Sekine.
264		1	_aSingapore _bSpringer Singapore _c2018
300			_a1 recurso en línea (VIII, 284 páginas 208 ilustraciones, 35 ilustraciones a color)
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF _2rda
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPart 1. Synthesis of Natural Oligonucleotides -- Chapter 1. Non-protected Synthesis of Oligonucleotides -- Chapter 2. Various Coupling Agents in the Phosphoramidite Method for Efficient Oligonucleotide Synthesis -- Chapter 3. Recent Development of Chemical Synthesis of RNA -- Chapter 4. RNA Synthesis Using the CEM Group -- Chapter 5. Liquid-Phase Synthesis of Oligonucleotides -- Chapter 6. Large-Scale Oligonucleotide Manufacturing -- Part 2: Synthesis and Properties of Artificial Oligonucleotides -- Chapter 1. Nucleosides and Oligonucleotides Incorporating 2-Thiothymine or 2-Thiouracil Derivatives as Modified Nucleobases -- Chapter 2. Site-Specific Modification of nucleobases in oligonucleotides -- Chapter 3. Four-Hydrogen-Bonding Base Pairs in Oligonucleotides: Design, Synthesis, and Properties -- Chapter 4. Photo-Cross-Linkable Artificial Nucleic Acid: Synthesis and Property of 3-Cyanovinylcarbazole-modified Nucleic Acids and Its Photo-induced Gene-Silencing Activity in Cells -- Chapter 5. Effects of 2´-O-Modifications on RNA Duplex Stability -- Chapter 6. 2',4'-Bridged Nucleic Acids Containing Plural Heteroatoms in the Bridge Moiety -- Chapter 7. Synthesis and Therapeutic Applications of Oligonucleotides Containing 2'-O,4'-C-Ethylene- and 3'-O,4'-C-Propylene-Bridged Nucleotides -- Chapter 8. RNA Bioisosters: Chemistry and Properties of 4'-ThioRNA and 4'-SelenoRNA -- Chapter 9. Development of Triplex Forming Oligonucleotide including Artificial Nucleoside Analogues for the Antigene Strategy -- Chapter 10. Chemical Synthesis of Boranophosphate Deoxyribonucleotides.
520	3		_aThis book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research.
988			_aEBSPRINGER_BIOMEDLIFE_2019
650		7	_9155839 _aBiotecnología farmacéutica _2
700	1		_aObika, Satoshi _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aSekine, Mitsuo _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _1http://viaf.org/viaf/147988610
776	0	8	_iPrinted edition: _z9789811319112
776	0	8	_iPrinted edition: _z9789811319136
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-1912-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _aSI _aSI _b06/2019 _cm _dz _feng _ggw _h0 _eIG _zSI