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336			_aTexto _btxt _2rdacontent
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
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008			181127s2018 gw | s |||| 0|eng d
020			_a9783030007379
024	7		_a10.1007/978-3-030-00737-9 _2doi
050		4	_aRB155 _b2018 EB
245	0	0	_aPrefoldins: the new chaperones _cedited by Nabil Djouder
264		1	_aCham _bSpringer International Publishing _c2018
300			_a1 recurso en línea (IX, 135 páginas) _b39 ilustraciones, 36 ilustraciones a color
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF _2rda
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1106
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPreface -- Structure of the molecular chaperone prefoldin -- Structure and function of archaeal prefoldin -- Role and functions of prefoldins -- Nuclear functions of prefoldins -- The yeast prefoldin Bud27 -- URI-like prefoldin complex -- HSP90 and its R2TP/Prefoldin-like cochaperone -- Role and functions of URI: mouse models for URI -- Nuclear function of URI-like prefoldin complex -- URI and androgen regulation. Index.
520	3		_aThis book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease. This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined. This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world.
988			_aEBSPRINGER_BIOMEDLIFE_2019
650		7	_aGenética médica _2embne _9144879
700	1		_aDjouder, Nabil _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030007362
776	0	8	_iPrinted edition: _z9783030007386
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-00737-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
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998			_aSI _aSI _aSI _b02/2019 _cm _dz _feng _ggw _h0 _eIG _zSI