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001			106872
003			ESmaUEC
005			20230102113317.0
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007			cr nn nnnaamaa
008			190201s2018 gw | s |||| 0|eng d
020			_a9783319911168 _9
024	7		_a10.1007/978-3-319-91116-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQP376 2018 EB
100	1		_aBennett, Maxwell _eautor _942576
245	1	0	_aStress, Trauma and Synaptic Plasticity _cby Maxwell Bennett, Jim Lagopoulos.
264		1	_aCham _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XXXIII, 231 páginas 47 ilustraciones, 18 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2rda
505	0		_aGrey matter changes in the brain following stress and trauma -- Synaptic changes responsible for grey matter changes in the brain of animal models following stress -- Identification of the core neural network subserving PTSD in animal models and their modulation -- Modulation of the core neural network in stress: the role of Brain Derived Neurotrophic Factor & LTP -- Modulation of the core neural network in stress: the role of Endocannabinoids & LTD -- Functioning of the core neural network in fear and extinction -- Modulation of the core synaptic network in extinction: the role of Brain Derived Neurotrophic Factor -- Appendix 1: F-actin determination of dendritic spine integrity -- Appendix 2: Regulation of NMDA receptors. .
520	3		_aThis book provides detailed insights into the cellular and molecular alterations that occur in the brain following stress and trauma. The changes to the grey matter in certain areas of the brain are similar in stressed humans and animals, with the most likely basis for these changes being the degeneration of synaptic connections. In the book's initial sections, the reader will learn about the core network of synaptic connections that are affected by stress and trauma disorders. These connections are chiefly modulated by dopamine, serotonin and Brain Derived Neurotrophic Factor (BDNF). In subsequent chapters, the NMDA-receptor-mediated plasticity of these synapses is discussed, with particular attention paid to how glucocorticoids can interfere with the function of BDNF and thereby affect the synapse's physical stability. The book concludes by integrating the observations made in the previous sections so as to present plausible hypotheses regarding the identity of the networks, synapses and molecular pathways that promote fear and extinction. Providing an up-to-date overview of the mechanisms of synaptic plasticity and physiological changes in the stressed and traumatized brain, this book will appeal to researchers, clinicians and students in the neurosciences.
650		7	_aCerebro _2embne _9139532
650		7	_aNeurociencias _2embne _9158907
700	1		_aLagopoulos, Jim _e. _4aut _4http://id.loc.gov/vocabulary/relators/aut _1http://viaf.org/viaf/607148451594215970008
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iPrinted edition: _z9783319911151
776	0	8	_iPrinted edition: _z9783319911175
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-91116-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
988			_aEBSPRINGER_BIOMEDLIFE_2019
998			_aSI _a_alco _a_vill _b01/2019 _cm _dz _ef _feng _ggw _h0
999			_c106872 _d106872 _x1