000 04241nam a22003975i 4500
001 106838
003 ESmaUEC
005 20230102113315.0
006 a||||fo|||| 00| 0
007 cr nn nnnaamaa
008 181102s2018 si | s |||| 0|eng d
020 _a9789811315688
_9
024 7 _a10.1007/978-981-13-1568-8
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
050 4 _aRC268.4
_b2018 EB
100 1 _aArora, Mansi
_eautor
_9669168
245 1 0 _aCancer RNome :
_bNature & Evolution
_cby Mansi Arora, Deepak Kaul
264 1 _aSingapore
_bSpringer Singapore
_c2018
300 _a1 recurso en línea (XII, 313 páginas)
_b51 ilustraciones, 50 ilustraciones a color
336 _aTexto
_btxt
_2rdacontent
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
_2rda
505 0 _a1. Section 1. RNome: Evolution and nature -- Chapter. 1.1. RNA world hypothesis -- Chapter.1.2. Various classes of RNAs (coding as well non-coding), their biosynthesis and basic functions -- 2. Section 2. Cellular RNome: Chromatin dynamics -- Chapter. 2.1. Chromatin modifications & transcription -- Chapter. 2.2. RNA modifications and epitranscriptomics -- Chapter. 2.3. Cellular RNome: Contribution of non-coding RNA -- 3. Section 3. Cancer RNome: Evolution and Sustenance.(How is cancer RNome different from RNome of healthy cell? How does the cancer RNome regulate the evolution as well as the sustenance of cancer?) -- Chapter. 3.1. Genome instability and mutation -- Chapter. 3.2. Tumor-promoting inflammation -- Chapter. 3.3. DNA methylation addiction -- Chapter. 3.4. Oncoviruses -- Chapter. 3.5. Sustained proliferative signaling -- Chapter. 3.6. Evasion of growth suppressors -- Chapter. 3.7. Replicative immortality -- Chapter. 3.8. Resisting Cell death -- Chapter. 3.9. Invasion and metastasis -- Chapter. 3.10. Angiogenesis induction.-Chapter. 3.11. Deregulated cellular energetics/Molecular sweet tooth -- Chapter. 3.12. Tumor Immune-evasion -- Chapter. 3.13. Cancer stem cells and tumor cell plasticity -- 4. Section 4. Cancer RNome: Therapeutic implications(Translational implications of the cancer RNome). Chapter. 4.1. RNAs as diagnostic/prognostic biomarkers -- Chapter. 4.2. RNAs in cancer therapy & chemo-resistance.
520 3 _aIn the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians.
650 7 _aCáncer
_xAspectos genéticos
_9273952
_2embne
700 1 _aKaul, Deepak
_eautor
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
710 2 _aSpringerLink (Online service)
_0http://id.loc.gov/authorities/names/no2005046756
_1http://viaf.org/viaf/148105729
_9106996
776 0 8 _iPrinted edition:
_z9789811315671
776 0 8 _iPrinted edition:
_z9789811315695
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-1568-8
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490 0 _aBiomedical and Life Sciences (Springer-11642)
942 _2lcc
988 _aEBSPRINGER_BIOMEDLIFE_2019
998 _aSI
_a_alco
_a_vill
_b01/2019
_cm
_dz
_ef
_feng
_ggw
_h0
999 _c106838
_d106838
_x1