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008			181102s2018 si | s |||| 0|eng d
020			_a9789811314353
024	7		_a10.1007/978-981-13-1435-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aRC935.A8 _b2018 EB
245	0	0	_aMuscle Atrophy _cedited by Junjie Xiao
264		1	_aSingapore _bSpringer Singapore _c2018
300			_a1 recurso en línea (XV, 624 páginas) _b76 ilustraciones, 52 ilustraciones a color
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2rda
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1088
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aAn overview of muscle atrophy -- Myofibers -- Muscle mass, quality, and composition changes during atrophy and sarcopenia -- Muscle changes during atrophy -- Skeleton muscle damage in intorauterine growth restriction -- The role of IGF-1 signaling in skeletal muscle atrophy -- mTOR signaling pathway and protein synthesis: from training to aging and muscle autophagy -- Past, present and future perspective of targeting myostatin and related signaling pathways to counteract muscle atrophy -- Hormones and muscle atrophy -- Ubiquitin-proteasome pathway and muscle atrophy -- Noncoding RNAs in muscle atrophy -- NF-kB and inflammatory cytokine signalling; role in skeletal muscle atrophy -- Redox homeostasis in age-related muscle atrophy -- Disturbed Ca2+ homeostasis in muscle wasting disorders -- Muscle atrophy in cancer -- The molecular mechanisms and prevention principles of muscle atrophy in aging -- Muscle atrophy in cardiovascular diseases -- Muscle atrophy in chronic kidney diseases -- Sarcopenia in liver disease: current evidence and issues to be resolved -- Muscle atrophy measurement as assessment method for low back pain patients -- Drugs of muscle wasting and their therapeutic targets -- Nutritional support to counteract muscle atrophy -- Nutritional considerations in preventing muscle atrophy -- Physical exercise for muscle atrophy -- To contrast and reverse skeletal muscle atrophy by Full-Body In-Bed Gym, a mandatory life-style for older olds and borderline mobility impaired persons -- Overview of FES-assisted cycling approaches and their benefits on functional rehabilitation and muscle atrophy -- The reversal of atrophy in human skeletal muscles by home-based Functional Electrical Stimulation after complete SCI lower motor neuron denervation -- Preverting muscle atrophy following strokes- a reappraisal -- Muscle atrophy: present and future.
520	3		_aThe book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book's fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.
650		7	_aMúsculos _9169472 _2embne _xEnfermedades
700	1		_aXiao, Junjie _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2011052519
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _9106996
776	0	8	_iPrinted edition: _z9789811314346
776	0	8	_iPrinted edition: _z9789811314360
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-1435-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc
988			_aEBSPRINGER_BIOMEDLIFE_2019
998			_aSI _a_alco _a_vill _b01/2019 _cm _dz _ef _feng _ggw _h0