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008			190108s2018 si | s |||| 0|eng d
020			_a9789811322006 _9
024	7		_a10.1007/978-981-13-2200-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQH506 _b2018 EB
245	0	0	_aIntegrative Structural Biology with Hybrid Methods _cedited by Haruki Nakamura, Gerard Kleywegt, Stephen K. Burley, John L. Markley
264		1	_aSingapore _bSpringer Singapore _c2018
300			_a1 recurso en línea (VI, 272 páginas) _b61 ilustraciones, 44 ilustraciones a color
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2rda
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1105
505	0		_a Part-1.Introduction and historical background -- Chapter 1.Overall introduction and rationale, with View from computational biology -- Chapter 2.Integrative/Hybrid Methods Structural Biology: Role of Macromolecular Crystallography -- Chapter 3.View from nuclear magnetic resonance spectroscopy -- Part- 2.New experimental tools enabling hybrid methods -- Chapter 4.Complementary use of electron cryomicroscopy and X-ray crystallography: Structural studies of actin and actomyosin filaments -- Chapter 5.Current solution NMR techniques for structure-function studies of proteins and RNA molecules -- Chapter 6.The PA tag: a versatile peptide tagging system in the era of integrative structural biology -- Chapter 7.Small angle scattering and structural biology: Data quality and model validation -- Chapter 8.Structural investigation of proteins and protein complexes by chemical cross-linking/mass spectrometry -- Chapter 9.Prediction of structures and interactions from genome information -- Chapter 10.A hybrid approach for protein structure determination combining sparse NMR with evolutionary coupling sequence data (EC-NMR) -- Chapter 11.Harnessing the combined power of SAXS and NMR -- Chapter 12.2D Hybrid analysis -- Part-3.New computational tools enabling hybrid methods -- Chapter 13.Hybrid methods for macromolecular modeling by molecular mechanics simulations with experimental data -- Chapter 14.Rigid-body fitting of atomic models on 3D density maps of electron microscopy -- Chapter 15.Hybrid methods for modeling protein structures using molecular dynamics simulations and small-angle X-ray scattering data -- Part-4.Data validation and archives for hybrid methods -- Chapter 16.Archiving pf integrative/hybrid models.
520	3		_aThis book presents a new emerging concept of "Integrative Structural Biology". It covers current trends of the molecular and cellular structural biology, providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and enables the readers to understand the hybrid methods. This book discusses how those integrative models should be represented, validated and archived. A unique highlight of this book is discussion of the data validation and archive, which are big problems in this filed along with the progress of this field. The researchers in biology will be interested in this book as a guide book for learning the current structure biology, but also those in structure biology may use this book as a comprehensive reference to cover broad topics.
650		7	_aBiología molecular _2embne _9139103
700	1		_aNakamura, Haruki _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _1http://viaf.org/viaf/257606283
700	1		_aKleywegt, Gerard _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBurley, Stephen K _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aMarkley, John L _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _1http://viaf.org/viaf/12461568
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iPrinted edition: _z9789811321993
776	0	8	_iPrinted edition: _z9789811322013
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-2200-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
988			_aEBSPRINGER_BIOMEDLIFE_2019
998			_aSI _a_alco _a_vill _b01/2019 _cm _dz _ef _feng _ggw _h0
999			_c106821 _d106821 _x1