000			04234nam a22003735i 4500
988			_aSpringer_Medicine_2018
999			_c106759 _d106759 _x1
001			106759
003			ES-MaUEC
005			20230102113312.0
006			a||||fo|||| 00| 0
007			cr nn 008mamaa
008			180416s2018 gw | s |||| 0|eng d
020			_a9783319713243
024	7		_a10.1007/978-3-319-71324-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC267 _b2018 EB
245	0	0	_aMethods and Biostatistics in Oncology : _bUnderstanding Clinical Research as an Applied Tool _cedited by Raphael. L. C. Araújo, Rachel P. Riechelmann
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XII, 348 páginas) _b58 ilustraciones, 37 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
490	0		_aMedicine (Springer-11650)
505	0		_aPreface -- Introduction -- 1. Background of scientific method in oncology -- 2. Writing a hypothesis for a oncology study -- 3. Type of variables and distributions -- 4. Testing measures of association -- 5. Sample size calculation for oncology trials -- 6. Uni and multivariate analysis (understanding of regressions) in cancer research -- 7. Survival analyses in cancer trials -- 8. The role of transversal and cohort studies in oncology -- 9. Design of retrospective and case-control studies in oncology -- 10. Minimizing differences by randomization -- 11. How to design phase I trials in oncology -- 12. The many different designs of phase II oncology trials -- 13. Superiority and non-inferiority phase III oncology trials -- 14. Phase IV oncology trials -- 15. Analysis of graphs in clinical cancer research -- 16. Identifying biases in clinical cancer research -- 17. Ethics in clinical cancer research -- 18. Cost-effectiveness studies in oncology -- 19. How to undertake outcomes research in oncology -- 20. Systematic review and meta-analysis of oncology studies -- 21. Meta-research in oncology -- 22. Analysis of quality of life and patient-reported outcomes in oncology -- Exercises -- Commented answers -- Glossary -- Remissive index.
520			_aThis book introduces and discusses the most important aspects of clinical research methods and biostatistics for oncologists, pursuing a tailor-made and practical approach. Evidence-based medicine (EBM) has been in vogue in the last few decades, particularly in rapidly advancing fields such as oncology. This approach has been used to support decision-making processes worldwide, sparking new clinical research and guidelines on clinical and surgical oncology. Clinical oncology research has many peculiarities, including specific study endpoints, a special focus on survival analyses, and a unique perspective on EBM. However, during medical studies and in general practice, these topics are barely taught. Moreover, even when EBM and clinical cancer research are discussed, they are presented in a theoretical fashion, mostly focused on formulas and numbers, rather than on clinical application for a proper literature appraisal. Addressing that gap, this book discusse s more practical aspects of clinical research and biostatistics in oncology, instead of relying only on mathematical formulas and theoretical considerations. Methods and Biostatistics in Oncology will help readers develop the skills they need to understand the use of research on everyday oncology clinical practice for study design and interpretation, as well to demystify the use of EBM in oncology.
650		7	_2embne _aCáncer _xInvestigación _9182523
700	1		_aAraújo, Raphael. L.C. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aRiechelmann, Rachel P. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783319713236
776	0	8	_iPrinted edition: _z9783319713250
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-71324-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2019 _dz _feng _ggw _h0