000			04574nam a22004215i 4500
988			_aSpringer_Medicine_2018
999			_c106738 _d106738 _x1
001			106738
003			ES-MaUEC
005			20230102113311.0
006			a||||fo|||| 00| 0
007			cr nn 008mamaa
008			180213s2018 gw | s |||| 0|eng d
020			_a9783319640969
024	7		_a10.1007/978-3-319-64096-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC280.P7 _b2018 EB
245	0	0	_aPrecision Molecular Pathology of Prostate Cancer _cedited by Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XIV, 570 páginas) _b50 ilustraciones, 48 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
490	0		_aMolecular Pathology Library _x1935-987X
490	0		_aMedicine (Springer-11650)
505	0		_aPart I. General principles -- Approach to patient -- Etiology -- Precursor and pre-invasive lesions of prostate cancer -- Prostatic adenocarcinoma: morphologic spectrum, Gleason scoring, etc -- Genetic susceptibility -- DNA damage repair, BRCA mutations, DNA adducts, SNPs -- Racial differences -- Cancer stem cells Part II. Molecular signatures of primary prostate cancer -- SNPs -- Copy number variation/chromosomal aberration (PTEN deletion, etc.) -- Gene fusions (TMPRSS2:ERG, etc.) -- Gene expression arrays -- Next generation sequencing (point mutations, indels, etc.) -- Epigenetic changes (chromatin remodeling, etc.) -- Proteomics -- Metabolomics -- miRNA and lncRNA Part III. Molecular signatures of advanced prostate cancer -- Lymph node metastasis -- Bone metastasis a -- RANKL, Src kinases, endothelins, bisphosphonates -- Visceral metastasis a -- Role of extracellular matrix, angiogenesis, epithelial-mesenchymal transition (EMT), inflammation -- Castration resistant prostate cancer (CRPC) -- Neuroendocrine prostate cancer (NEPC) Part IV. Key molecular pathways in prostate cancer development and progression -- Androgen receptor in carcinogenesis -- Androgen receptor in progression (CRPC) -- PI3K/Akt/mTOR/PTEN and ERK/MAPK pathways -- Cell cycle regulators (p53, etc.) -- DNA damage repair --         Tyrosine kinase signaling (EGFR, VEGFR, PDGFR, FGFR, IGFR, etc.) -- Cytoskeletal function (microtubules and taxane therapy) Part V. Precision medicine approach: Diagnosis, treatment, prognosis -- Molecular diagnosis -- Molecular imaging -- Molecular prognostic markers/tests -- Molecular targeted therapies -- Towards molecular classification of prostate cancer.
520			_aThis volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches.  The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease.  The book consists of five sections which provide insight about the following:  (1) General principles;  (2) Molecular signatures of primary prostate cancer;  (3) Molecular signatures of advanced prostate cancer;  (4) Key molecular pathways in prostate cancer development and progression;  (5) Precision medicine approach: Diagnosis, treatment, prognosis.   Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.  .
650		7	_2embne _9182337 _aPróstata _xCáncer
700	1		_aRobinson, Brian D. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aMosquera, Juan Miguel. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aRo, Jae Y. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aDivatia, Mukul. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783319640945
776	0	8	_iPrinted edition: _z9783319640952
776	0	8	_iPrinted edition: _z9783319877211
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-64096-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2019 _dz _feng _ggw _h0