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020 _a9783319093369
024 7 _a10.1007/978-3-319-09336-9
_2doi
040 _bspa
_dES-MaUEC
050 4 _aQP303
_b.T446 2015 EB
245 1 4 _aThe Mechanobiology of Obesity and Related Diseases
_cedited by Amit Gefen, Dafna Benayahu.
264 1 _aCham
_bSpringer International Publishing
_c2015
300 _a1 recurso en línea (X, 296 páginas)
336 _2rdacontent
_aTexto (visual)
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
490 0 _aStudies in Mechanobiology, Tissue Engineering and Biomaterials,
_x1868-2006 ;
_v16
490 0 _aEngineering (Springer-11647)
505 0 _aMechanical behavior and properties of adipose tissue -- Mathematical models of adipose tissue dynamics -- Mechanical stretching and signaling pathways in adipogenesis- Role of mechanical stimulations in directing mesenchymal stem cell adipogenesis -- The vicious cycle of estrogen consumption and obesity: The role of mechanotransduction -- Extracellular matrix remodeling and mechanical stresses as modulators of adipose tissue metabolism and inflammation -- The Impact of Obesity and Weight Loss on Gait in Adults -- Excessive Weight Bearing Compromises Foot Structure and Function across the Lifespan -- Obesity, Osteoarthritis and Aging: The Biomechanical Links -- Impaired neutrophil mechanoregulation by fluid flow: A potential contributing factor for microvascular dysfunction in obesity -- Mechanotransduction and the myogenic response in diabetes -- Role of adipose cells in tumor microenvironment.
520 3 _aThis volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases. There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.
988 _aEBSPRINGER_2018
650 7 _aKinesiología
_2embne
_9138567
700 1 _aGefen, Amit
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_0http://id.loc.gov/authorities/names/n2009185522
_1http://viaf.org/viaf/101334746/
_999326
700 1 _aBenayahu, Dafna.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_0http://id.loc.gov/authorities/names/n2015181975
_1http://viaf.org/viaf/308257403/
776 0 8 _iEdición impresa:
_z9783319093376
776 0 8 _iEdición impresa:
_z9783319093352
776 0 8 _iEdición impresa:
_z9783319376264
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-09336-9
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b03/2019
_dz
_eIG
_zSI