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336			_aTexto _btxt _2rdacontent
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
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020			_a9783319660844
024	7		_a10.1007/978-3-319-66084-4 _2doi
050		4	_aRA1199 _b2018 EB
245	1	2	_aA Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment _cedited by Natàlia Garcia-Reyero, Cheryl A. Murphy.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XIV, 422 páginas 77 ilustraciones,64 ilustraciones a color)
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_a1. Introduction -- Part I: Biology -- 2. "Non-model" species for eco and human health risk assessment -- 3.The fish embryo as a model  for eco-toxicology and other potential models -- 4.Invertebrates/Plants -- 5.Behavioral/Neurobehavioral linkages to AOPs -- 6. Species extrapolation - common pathways etc -- 7.  Life History Evolution, incorporating evolutionary processes into AOPs to extrapolate -- Part II: Incorporating Biology into AOPs -- 8.Use of HTS assays to infer MIEs -- 9. AOP development: how to infer and define KER -- 10. The development of quantitative AOPs -- Part IV: Incorporating Modeling into AOPs.-11.Computational approaches (network science, etc) in AOPs: linking molecular datasets -- 12.Computational approaches : Dynamic Energy Budgets -- 13.  Modeling approaches in AOPs: extrapolation from individual to population -- 14.  Modeling approaches that augment AOPs: GUTS, QSAR, TKTD PBTKTD -- 15.  Exposure science and other stressors? How to incorporate -- 16.  AOP as an organizing framework and implications for biological science-AOP evolution -- 17. Use and acceptance of AOPs for regulatory applications, use of AOPs in human risk assessment, and legislation. .
520	3		_aSocial pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.
650		7	_aSistemas biológicos _2embne _9403517
650		7	_aToxicología _2embne _9140328
700	1		_aGarcia-Reyero, Natàlia _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2018186421
700	1		_aMurphy, Cheryl A _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2018186422 _1http://viaf.org/viaf/25153651656755780400
776	0	8	_iEdición impresa: _z9783319660820
776	0	8	_iEdición impresa: _z9783319660837
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-66084-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _b03/2019 _cm _dz _ep _feng _ggw _h0