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008			180216s2018 si | s |||| 0|eng d
020			_a9789811073472 _9
024	7		_a10.1007/978-981-10-7347-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aRB155 2018 EB
100	1		_aKangueane, Pandjassarame _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _0http://id.loc.gov/authorities/names/n2008185398 _1http://viaf.org/viaf/26547035
245	1	0	_aProtein-Protein and Domain-Domain Interactions _cby Pandjassarame Kangueane, Christina Nilofer.
264		1	_aSingapore _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XIX, 207 páginas 161 ilustraciones,82 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
505	0		_aModule 1. Preface -- Module 2. Introduction to protein complexes -- Module 3. Historical advancement -- Module 4. Databases for protein complexes -- Module 5. Types of protein complexes -- Module 6. Hetero dimer protein complexes -- Module 7. Homo dimer protein complexes -- Module 8. Multimer protein complexes -- Module 9. Interfaces in protein complexes -- Module 10. Principles of protein-protein binding -- Module 11. Homodimer folding and binding -- Module 12. Gene fusion and protein complexes -- Module 13. Domain-domain interactions -- Module 14. Protein docking: Methods, software tools and servers -- Module 15. Protein complexes, pathways and networks -- Module 16. Protein complexes and biological functions -- Module 17. Protein complexes in diseases -- Module 18. Protein complexes in drug discovery & vaccine development -- Module 19. Protein complexes in genome and proteome analysis -- Module 20. Conclusions & challenges.
520	3		_aThis book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins.
650		7	_aBioinformática _2embne _9160489
650		7	_aBioquímica _2embne _9138639
700	1		_aNilofer, Christina _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _0http://id.loc.gov/authorities/names/n2018188325 _1http://viaf.org/viaf/10154074425911741642
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9789811073465
776	0	8	_iEdición impresa: _z9789811073489
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-10-7347-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
988			_aEBSPRINGER_2018
998			_aSI _b02/2019 _cm _dz _ep _feng _ggw _h0
999			_c100941 _d100941 _x1